用左炔诺孕酮对接受手术治疗后的子宫内膜息肉患者进行辅助治疗的效果探讨

Effect of levonorgestrel on adjuvant therapy of endometrial polyps after surgical treatment

目的:探讨用左炔诺孕酮对接受手术治疗后的子宫内膜息肉患者进行辅助治疗的效果。方法:对惠州市第六人民医院2020年2月至2021年2月收治的66例子宫内膜息肉患者进行分组研究。将其随机分为观察组和对照组。在两组患者接受手术治疗后,采用地屈孕酮对对照组患者进行辅助治疗,采用左炔诺孕酮对观察组患者进行辅助治疗,然后对比两组患者的临床疗效。结果:观察组患者治疗的总有效率高于对照组患者,P<0.05。治疗后,观察组患者血清雌激素受体(ER)、表皮生长因子受体(EGFR)、孕激素受体(PR)的表达水平、不良反应的发生率均低于对照组患者,P<0.05。结论:用左炔诺孕酮对接受手术治疗后的子宫内膜息肉患者进行辅助治疗的效果较好,可显著降低其血清ER、EGFR及PR的表达水平,且安全性较高。

Objective:To investigate the effect of levonorgestrel in the adjuvant treatment of endometrial polyps after surgical treatment.Methods:66 cases of endometrial polyps admitted to The Sixth People’s Hospital of Huizhou from February 2020 to February 2021 were divided into groups.They were randomly divided into observation group and control group.After surgical treatment in the two groups of patients,dydrogestrel was used for adjuvant treatment in the control group,levonorgestrel was used for adjuvant treatment in the observation group,and then the clinical efficacy of the two groups of patients was compared.Results:The total effective rate of observation group was higher than control group,P<0.05.After treatment,the expression levels of serum estrogen receptor(ER),epidermal growth factor receptor(EGFR),progesterone receptor(PR)and the incidence of adverse reactions in observation group were lower than those in control group,P<0.05.Conclusion:Levonorgestrel is effective in adjuvant therapy for patients with endometrial polyps after surgical treatment,and can significantly reduce the expression levels of ER,EGFR and PR in serum,with high safety.