摘要
JAK2-STAT3信号通路作为细胞内传递信号的主链,在细胞增殖、凋亡、侵袭、迁移及免疫应答等活动中起重要作用。该通路由细胞因子和干扰素触发,能迅速地将细胞外信号转导到细胞核中,在头颈部鳞状细胞癌、肺癌、食管癌、胃癌、肝癌、乳腺癌、骨髓增生性肿瘤等多种肿瘤中存在异常表达。深入了解JAK2-STAT3信号通路的致癌机制,可为临床治疗肿瘤及判断预后提供新的思考。
JAK2-STAT3 signaling pathway,as the main chain of intracellular signal transmission,plays an important role in cell proliferation,apoptosis,invasion,migration and immune response.Triggered by cytokines and interferon,this pathway can quickly transduce extracellular signals into the nucleus,and it has abnormal expression in various tumors,such as squamous cell carcinoma of the head and neck,lung cancer,esophageal cancer,gastric cancer,liver cancer,breast cancer and myeloproliferative neoplasms.Further understanding of the carcinogenic mechanism of JAK2-STAT3 signaling pathway can provide new ideas for clinical treatment of tumors and prognosis.
作者
罗盼
曾艳
吴伟莉
Luo Pan;Zeng Yan;Wu Weili(Department of Oncology,School of Clinical Medicine,Guizhou Medical University,Guiyang 550000,China;Department of Oncology,Affiliated Hospital of Guizhou Medical University,Guiyang 550000,China;Depart-ment of Head and Neck Oncology,Cancer Hospital Affiliated of Guizhou Medical University,Guiyang 550000,China)
出处
《国际肿瘤学杂志》
CAS
2021年第12期739-742,共4页
Journal of International Oncology
基金
贵州省科技计划(黔科合基础〔2017〕)(1148)
贵州省教育厅创新群体重大研究项目(黔教合KY字〔2017〕)(038)。
