Toll样受体4对新生儿坏死性小肠结肠炎作用的研究现状

Research advances in the role of Toll-like receptor 4in neonatal necrotizing enteroeolitis

新生儿坏死性小肠结肠炎(NEC)是新生儿尤其是早产儿肠道炎症和坏死性疾病。它具有发病率高、发病机制复杂、死亡率高、后遗症严重等特点。NEC发病与早产、肠道微生物定植、肠内喂养、遗传等有关。近年,分子水平机制的研究成为热点,发现Toll样受体4(TLR4)在NEC发病中起关键作用。本文就最新的关于TLR4对NEC作用的研究进行综述,旨在增加对NEC的认识,为制定预防和治疗策略提供帮助。

Neonatal necrotizing enterocolitis(NEC)is an inflammatory and necrotizing disease of the intestine in neonates,especially in premature infants.It is characterized by high incidence rate,complex pathogenesis,high mortality and serious sequelae.The incidence of NEC is related to preterm birth,intestinal microbial colonization,enteral feeding and genetics.In recent years,research on molecular-level mechanisms has become a hot topic,and Toll-like receptor 4(TLR4)is found to play a key role in the pathogenesis of NEC.This article reviews the latest studies on the role of TLR4in NEC,aiming to increase the understanding of NEC and to provide reference for the development of prevention and treatment strategies.