探讨痕量胺受体1在抽动秽语综合征发病机制中的重要性

Importance of trace amine receptor 1 in pathogenesis of Gilles de la Tourette syndrome

痕量胺受体1(trace amine receptor 1,TAAR1)是2001年被发现的G蛋白偶联受体(G protein-coupled receptor,GPCR)家族新成员。相关研究发现,痕量胺(trace amine,TA)有高度敏感性,能够介导TA调控多巴胺(dopamine,DA)能神经元的活动,其本身也是DA能系统的调节剂,与DA能系统功能是否正常联系密切。DA能系统失常也会引起抽动秽语综合征(Gilles de la Tourette syndrome,TS),所以TAAR1为探究TS发病机制提供了新的靶点和方向。

Trace amine receptor 1(TAAR1)is a new member of the G protein-coupled receptor(GPCR)family which was discovered in 2001. Related studies have found that trace amine(TA)is highly sensitive and can mediate TA regulation of the activity of dopamine(DA)neurons. TAAR1 itself is also a regulator of the DA system,which is closely related to the normal function of the DA system. The disorder of DA energy system can also lead to Gilles de la Tourette syndrome(TS). Therefore,TAAR1 provides a new target and direction for exploring the pathogenesis of TS.