鼻腔鼻窦血管外皮细胞瘤一例并文献分析

Sinonasal-type hemangiopericytoma:a case report and literature analysis

目的探讨鼻腔鼻窦血管外皮细胞瘤临床特点,为治疗及预后提供参考。方法回顾性分析我院就诊的1例鼻腔鼻窦血管外皮细胞瘤患者的临床和影像资料,并通过文献复习以往所报道病例,以是否复发分为两组,未复发组17例和复发组15例,未复发组系随访3年以上未复发者,观察和分析两组的临床特点。结果未复发病例组男12例,女5例,年龄12~70岁,平均年龄50.29±16.48岁,治疗方法:5例采用手术+放疗,其余12例采用手术治疗,随访时间均超过3年,未见复发。复发病例组男10例,女5例,年龄22~64岁,平均年龄38.93±13.91岁,治疗方法:8例采用手术+放疗,1例采用手术+化疗,4例采用单纯手术或单纯放疗,2例采用手术联合放化疗。随访结果:2例再次复发手术后随访3年以上未见肿瘤再次复发,而其余13例为多次复发或带瘤生长或复发死亡病例。结论复发组的平均年龄较未复发组更年轻,多数未复发组患者单纯手术完整切除就可以有效控制疾病,而多数复发组患者即使综合治疗也不能很好地控制疾病进展。

Objective To explore the clinical features of sinonasal-type hemangiopericytoma(SNTHPC),and to provide reference for treatment and prognosis.Methods The clinical and imaging data of one case with SNTHPC were analyzed retrospectively.Cases reported in the past were reviewed through literature.The patients were divided into two groups according to whether the disease recurred or not,17 cases in the non-recurrence group and 15 cases in the recurrence group.The non-recurrence group referred to those who have not recurred during 3 years of follow-up.The clinical characteristics of the two groups were observed and analyzed.Results There were 12 males and 5 females in the non-recurrence group,with an average age of 50.29±16.48 years old,ranging from 12 to 70 years old.The treatment regime included:5 cases were treated with surgery and radiotherapy,the other 12 cases were treated with surgery.All patients were followed up for more than 3 years without recurrence.There were 10 males and 5 females in the recurrence group,with an average age of 38.93±13.91 years old,ranging from 22 to 64 years old.The treatment regime included:8 cases were treated with surgery and radiotherapy,1 case with surgery and chemotherapy,4 cases with surgery or radiotherapy alone,and 2 cases with surgery combined with radiotherapy and chemotherapy.Follow-up results showed that 2 cases had no recurrence during 3 years of follow-up,while the remaining 13 cases had multiple recurrences or died with tumor growth or recurrence.Conclusion The average age of the recurrence group is younger than that of the non-recurrence group.Most patients in the non-recurrence group can effectively control the disease by complete resection,while most of patients in the recurrence group cannot control the disease progression well even with comprehensive treatment.