类器官组织在感染性疾病研究中的应用

The application of organoid tissue model in the pathogen infection diseases

类器官(organoid)是体外3D培养组织干细胞所形成的多功能细胞团,具有自身增殖和多向分化的能力,在空间和结构上与来源器官组织的基因、结构和功能相似,可用于模拟体内组织细胞生长、分化及器官形成过程,在药物筛选与评价、生物医学材料及组织工程等方面具有重要的应用潜能。当前在感染性疾病研究方面,越来越多数据表明不同类器官组织可用于在体外模拟病原入侵和引发疾病过程。鉴于此,本文对类器官组织在病原感染相关疾病模型上的研究进展及其应用前景进行综述。

Organoid is a multicellular cluster formed by tissue stem cells cultured in 3D invitro,which has the ability of self-proliferation and multi-directional differentiation.It can be used to simulate the growth,differentiation and organ formation process of tissue cells in vivo for drug screening,biomedical materials evaluation,and tissue engineering.Increasing evidence shows that different kinds of organs and tissues can be used to simulate the process of pathogen invasion in vitro.This review summarizes the research progress and application prospect of organoids model in pathogenic infection related diseases.