乳腺癌患者内分泌治疗期感知认知功能现况调查

Cross-sectional study on perceived cognitive function among breast cancer patients on endocrine therapy

目的了解乳腺癌患者内分泌治疗期感知认知功能现状,并分析其影响因素。方法应用患者一般资料调查表、癌症患者功能评估-认知功能量表、匹兹堡睡眠质量指数、国际体力活动问卷、医院焦虑抑郁量表、慢性病治疗功能评估-疲乏量表对366例乳腺癌患者进行调查。结果乳腺癌内分泌治疗期患者感知认知功能总分108.46±16.20。多元线性回归分析结果显示,年龄、既往激素替代治疗、静坐时间、疲乏、焦虑与日间功能障碍是影响患者认知功能的主要因素(均P<0.01)。结论医护人员应重视患者内分泌治疗期间认知功能的变化,通过改善疲乏与焦虑、缩短静坐时间、减轻日间功能障碍方面制定干预策略,改善患者感知认知功能水平。

Objective To investigate the level of perceived cognitive function in Chinese breast cancer patients on endocrine therapy,and to explore the influencing factors.Methods A total of 366 breast cancer patients were included in the cross-sectional study,and filled out the demographic questionnaire,Functional Assessment of Cancer Therapy-Cognitive Scale(FACT-Cog),Pittsburgh Sleep Quality Index(PSQI),International Physical Activity Questionnaire(IPAQ),Hospital Anxiety and Depression Scale(HADS)and Functional Assessment of Chronic illnesses Therapy-Fatigue(FACIT-Fatigue).Results The total cognitive function scores averaged(108.46±16.20)points.Multiple linear regression analysis showed that,age,previous hormone replacement therapy,sedentary time,fatigue,anxiety and daytime dysfunction were the main factors affecting cognitive function of breast cancer patients(P<0.01 for all).Conclusion Clinical workers should pay attention to the change of cognitive function of breast cancer patients during endocrine therapy.Intervention measures which aim at alleviating fatigue and anxiety,shortening the sedentary time,reducing daytime dysfunction,are helpful to improve patients′cognitive function level.