成人造血干细胞移植后口腔黏膜炎护理最佳证据总结

Best evidence summary for care of oral mucositis developed after hematopoietic stem cell transplantation in adults

目的查找并筛选成人接受造血干细胞移植后口腔黏膜炎护理的相关证据,并进行最佳证据总结。方法检索指南、BMJ Best Practice、CINAHL、CNKI、Embase、JBI循证卫生保健中心数据库、PubMed、The Cochrane Library, WanFang等数据库中成人造血干细胞移植口腔黏膜炎的相关文献。由2名循证小组成员对文献进行检索、分类、评价,另外2名循证小组成员对符合JBI质量标准的文献进行证据汇总。结果共纳入15篇文献,其中包括1篇指南,1篇证据总结,9篇系统评价,1篇Meta分析,2篇随机对照试验,1篇专家共识,共总结出13条关于成人造血干细胞移植后口腔黏膜炎护理的最佳证据。结论成人造血干细胞移植后口腔黏膜炎的最佳证据可供医护人员评估患者口腔、开展口腔健康教育、及时采取预防措施和正确治疗口腔黏膜炎。

Objective To summarize the best available evidence for care of oral mucositis developed after hematopoietic stem cell transplantation in adults. Methods Literature on oral mucositis in the databases of guidelines, BMJ Best Practice, CINAHL, CNKI, Embase, JBI Evidence-based Health Care Center, PubMed, the Cochrane Library, WanFang, etc., was retrieved, classified, and appraised by 2 members of the evidence-based team. Then 2 others extracted and summarized the evidence that met JBI quality standards. Results A total of 15 publications were included, namely 1 guideline, 1 evidence summary report, 9 systematic reviews, 1 Meta-analysis, 2 randomized controlled trials, 1 expert consensus report. From the publications, 13 pieces of best evidence on oral mucositis after adult hematopoietic stem cell transplantation were summarized. Conclusion The summarized best evidence on oral mucositis after adult hematopoietic stem cell transplantation could help medical staff to accurately assess patients′ oral cavity, carry out oral health education, timely take preventive measures and correctly treat oral mucositis.