孕产期抑郁症生物标志物的研究进展

Research progress in biological markers of perinatal depression

孕产期抑郁症是围产期常见的并发症之一,严重影响母儿身心健康。目前,早期诊断孕产期抑郁症尤为困难,客观有效的生物学标志物对早发现早治疗孕产期抑郁症意义重大。近年来探索孕产期抑郁症早期诊断的生物标志物成为研究热点,主要在性激素、神经内分泌相关激素、免疫炎症分子、遗传及表观遗传学等方面。本文就近年来孕产期抑郁症生物学标志物的研究进展进行综述。

Perinatal depression,one of the most common complications in the perinatal period,has a significant impact on the physical and mental health of mothers and children.At present,it is difficult to diagnose perinatal depression at an early stage,so objective and effective biomarkers are of great significance for the early detection and treatment of perinatal depression.In recent years,the exploration of biomarkers for early diagnosis of peri⁃natal depression has become a hot research topic,mainly in sex hormones,neuroendocrine-related hormones,immuno-inflammatory molecules,genetics,and epigenetics.This article reviews the research progress of the bio⁃markers of perinatal depression in recent years.