摘要
孕产期抑郁症是围产期常见的并发症之一,严重影响母儿身心健康。目前,早期诊断孕产期抑郁症尤为困难,客观有效的生物学标志物对早发现早治疗孕产期抑郁症意义重大。近年来探索孕产期抑郁症早期诊断的生物标志物成为研究热点,主要在性激素、神经内分泌相关激素、免疫炎症分子、遗传及表观遗传学等方面。本文就近年来孕产期抑郁症生物学标志物的研究进展进行综述。
Perinatal depression,one of the most common complications in the perinatal period,has a significant impact on the physical and mental health of mothers and children.At present,it is difficult to diagnose perinatal depression at an early stage,so objective and effective biomarkers are of great significance for the early detection and treatment of perinatal depression.In recent years,the exploration of biomarkers for early diagnosis of peri⁃natal depression has become a hot research topic,mainly in sex hormones,neuroendocrine-related hormones,immuno-inflammatory molecules,genetics,and epigenetics.This article reviews the research progress of the bio⁃markers of perinatal depression in recent years.
作者
章柳宵
Obore Nathan
虞天一
钱惠勤
张媛
于红
ZHANG Liuxiao;OBORE Nathan;YU Tianyi;QIAN Huiqin;ZHANG Yuan;YU Hong(Medical School of Southeast University,Nanjing 210009;Southeast University Affiliated Zhongda Hospital,Nanjing 210009,China)
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2022年第1期120-124,共5页
Journal of China Pharmaceutical University
基金
江苏省妇幼健康科研资助项目(No.F201810)。
关键词
孕产期抑郁症
生物学标志物
早期诊断
进展
perinatal depression
biological markers
early diagnosis
advances