冠心病患者冠状动脉支架植入术前血清LOX-1表达与术后冠脉再狭窄发生的关系研究

Study on the Relationship Between Serum LOX-1 Expression Before Percutaneous Coronary Intervention and Occurrence of Postoperative Coronary Restenosis in Patients with Coronary Heart Disease

目的探讨冠心病(CHD)患者冠状动脉支架植入(PCI)术前血清LOX-1表达与术后冠脉再狭窄发生的关系。方法选取行PCI治疗的98例CHD患者,检测术前血清LOX-1水平,统计术后冠脉再狭窄发生情况,分析术前血清LOX-1表达与PCI术后冠脉再狭窄的相关性。结果98例CHD患者PCI术后冠脉再狭窄发生率为9.18%;冠脉再狭窄患者的术前血清LOX-1水平显著高于冠脉无再狭窄患者(P<0.05);ROC曲线显示术前血清LOX-1水平预测CHD患者PCI术后冠脉再狭窄发生的AUC值为0.738,具有一定预测性能。结论CHD患者PCI术后冠脉再狭窄的发生与其术前血清LOX-1表达密切相关。

Objective To explore the relationship between serum LOX-1 expression before percutaneous coronary intervention(PCI)and occurrence of postoperative coronary restenosis in patients with coronary heart disease(CHD).Methods 98 patients with CHD who underwent PCI were selected.The preoperative serum LOX-1 level was detected and the occurrence of postoperative coronary restenosis after surgery was counted to analyze the relationship between preoperative serum LOX-1 expression and occurrence of postoperative coronary restenosis.Results The incidence of coronary restenosis after PCI in 98 CHD patients was 9.18%.The preoperative serum LOX-1 level in patients with coronary restenosis was significantly higher than that in patients without coronary restenosis(P<0.05).ROC curve showed that the A UC value of preoperative serum LOX-1 level in predicting the occurrence of coronary restenosis after PCI in CHD patients was 0.738,which had certain predictive performance.Conclusions The occurrence of coronary restenosis after PCI in CHD patients is closely related to the preoperative serum LOX-1 expression.