超分子水杨酸治疗轻中度痤疮的临床效果与安全性

Clinical efficacy and safety of supramolecular salicylic acid in the treatment of mild to moderate acne

目的观察超分子水杨酸治疗轻中度痤疮的临床效果与安全性。方法选取2019年1-7月重庆市中医院收治的轻中度痤疮患者72例,依照随机对照原则分为观察组和对照组,各36例。对照组接受常规治疗,观察组予超分子水杨酸治疗。比较2组患者治疗效果,治疗前后皮损评分变化及不良反应(皮肤瘙痒、皮肤干燥及脱屑)发生情况。结果观察组患者治疗总有效率为94.44%,高于对照组的77.78%(χ^(2)=4.181,P=0.041);治疗1个疗程后,2组粉刺、丘疹、脓疱评分均较治疗前下降,且观察组低于对照组(P均<0.01);观察组不良反应总发生率为5.56%,对照组为13.89%,2组比较差异无统计学意义(χ^(2)=0.633,P=0.426)。结论超分子水杨酸治疗轻中度痤疮的临床疗效肯定,操作简单且安全性高,值得临床推广应用。

Objective To observe the clinical effect and safety of supramolecular salicylic acid in the treatment of mild to moderate acne.Methods 72 patients with mild to moderate acne treated in Chongqing Hospital of Traditional Chinese Medicine from January to July 2019 were selected.According to the principle of random control,they were divided into observation group and control group,with 36 cases in each group.The control group received routine treatment,and the observation group was treated with supramolecular salicylic acid.The treatment effects,skin lesion score changes and adverse reactions(skin pruritus,dry skin and desquamation) before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 94.44%,higher than 77.78% of the control group(χ^(2)= 4.181,P = 0.041).After one course of treatment,the scores of acne,papules and pustules in the two groups were lower than those before treatment,and the scores in the observation group were lower than those in the control group(P < 0.01).The total incidence of adverse reactions was 5.56% in the observation group and 13.89% in the control group.There was no significant difference between the two groups(χ^(2)= 0.633,P = 0.426).Conclusion Supramolecular salicylic acid is effective in the treatment of mild to moderate acne.Its operation is simple and safe,which is worthy of clinical application.