抗银一号治疗寻常型银屑病血热证的临床效果及对血清炎性因子的影响

Clinical effect of Kangyin No. 1 on blood-heat syndrome of psoriasis vulgaris and its effect on serum inflammatory factors

目的观察抗银一号治疗寻常型银屑病血热证的临床效果及对血清炎性因子的影响。方法选取2018年1月-2020年1月泉州市皮肤病防治院门诊收治的寻常型银屑病血热证患者100例,依照随机数字表法分为观察组和对照组,各50例。对照组予阿维A胶囊治疗,观察组予抗银一号治疗。2组均以4周为1个疗程,连续治疗2个疗程。比较2组治疗2个疗程后临床效果,治疗前、治疗1个疗程与治疗2个疗程后银屑病面积与严重性指数(PASI)评分变化与炎性因子[白细胞介素-17(IL-17)、白细胞介素-22(IL-22)]水平,IL-17、IL-22水平与PASI评分相关性及2组不良反应发生情况。结果观察组患者治疗显效率为90.00%,对照组为86.00%,2组比较差异无统计学意义(χ^(2)=0.379,P=0.538);2组治疗后各时点PASI评分均呈现明显下降趋势(P均<0.01),但各时点2组间比较差异无统计学意义(P> 0.05);2组治疗后各时点的IL-17、IL-22水平均呈明显下降趋势(P <0.01),且观察组下降各时点均更为明显(P <0.01);采用Spearman相关性检验法来分析2组患者PASI评分与血清细胞因子检测结果的关联性,结果表明二者之间存在正相关性(P <0.01);2组不良反应总发生率比较差异无统计学意义(P> 0.05)。结论抗银一号治疗寻常型银屑病血热证的临床效果显著,可有效调控炎性因子水平,降低PASI评分,值得临床推广应用。

Objective To observe the clinical effect of Kangyin No.1 on blood-heat syndrome of psoriasis vulgaris and its effect on serum inflammatory factors.Methods One hundred patients with psoriasis vulgaris blood-heat syndrome treated in the outpatient department of Quanzhou Skin Disease Prevention and Treatment Hospital from January 2018 to January 2020 were selected.According to the random number table method,they were divided into observation group and control group,with 50 cases in each group.The control group was treated with acitretin capsule and the observation group was treated with Kangyin No.1.The two groups were treated for 2 consecutive courses with 4 weeks as a course of treatment.The clinical effects,the changes of psoriatic area and severity index(PASI) score and the levels of inflammatory factors(IL-17 and IL-22) before treatment,one course of treatment and two courses of treatment,the correlation between the levels of IL-17 and IL-22 and PASI score,and the occurrence of adverse reactions in the two groups were compared.Results The effective rate was 90.00% in the observation group and 86.00% in the control group.There was no significant difference between the two groups(χ^(2)= 0.379,P = 0.538).The PASI scores of the two groups showed a significant downward trend at each time point after treatment(all P < 0.01),but there was no significant difference between the two groups at each time point(P > 0.05).The levels of IL-17 and IL-22 in the two groups decreased significantly at each time point after treatment(P < 0.01),and the decrease was more obvious in the observation group(P < 0.01).Spearman correlation test was used to analyze the correlation between PASI score and serum cytokines in the two groups.The results showed that there was a positive correlation between them(P < 0.01).There was no significant difference in the total incidence of adverse reactions between the two groups(P > 0.05).Conclusion Kangyin No.1 has significant clinical effect in the treatment of blood-heat syndrome of psoriasis vulgaris.It can effectively regulate the level of inflammatory factors and reduce PASI score.It is worthy of clinical application.