OPRM1 A118G基因多态性与艾森克人格类型和疼痛敏感性相关性研究

Correlation of OPRM1 A118G gene polymorphism with Eysenck personality type and pain sensitivity

目的探讨OPRM1 A118G基因多态性与艾森克人格类型和疼痛敏感性的相关性。方法选择2018年1月—2020年12月泸州市人民医院由急诊医学部转普外科住院的手术患者。术前采用艾森克人格问卷调查患者人格类型并使用电刺激仪测定痛阈和耐痛阈,利用聚合酶链反应-限制性片段长度多态性分析技术检测患者外周静脉血OPRM1 A118G基因型。根据分型结果将患者分为野生纯合子(A/A)组、突变杂合子(A/G)组、突变纯合子(G/G)组。分析3组患者的一般情况、疼痛敏感性、艾森克人格问卷评分、艾森克人格类型的差异性和艾森克人格类型与疼痛敏感性的相关性。结果共纳入患者356例。其中,A/A组174例,A/G组136例,G/G组46例。OPRM1 A118G基因突变率为32.00%。3组患者的疼痛敏感性(痛阈、耐痛阈)及内外向、神经质、掩饰性人格类型评分比较,差异均有统计学意义(P<0.05)。3组患者内外向和精神质型人格类型比较,差异均有统计学意义(P<0.05)。不同内外向和精神质人格类型中的痛阈及耐痛阈比较,差异均有统计学意义(P<0.05)。结论OPRM1 A118G基因多态性和艾森克人格类型均对疼痛敏感性有影响,且二者之间也呈相关性。

Objective To investigate the correlation between OPRM1 A118 G gene polymorphism and Eysenck personality type and pain sensitivity.Methods The surgical patients who were transferred from Department of Emergency Medicine to Department of General Surgery of Luzhou People’s Hospital between January 2018 and December 2020 were selected.Before surgery,Eysenck Personality Questionnai(EPQ)was used to investigate the patient’s personality type,and the pain threshold and pain tolerance threshold were determined by electric stimulation instrument.The OPRM1 A118 G genotype of peripheral venous blood was detected by polymerase chain reactionrestriction fragment length polymorphism analysis technique.Patients were divided into wild homozygous(A/A)group,mutant heterozygous(A/G)group and mutant homozygous(G/G)group according to the typing results.The general condition,pain sensitivity,EPQ score,difference of Eysenck personality type and correlation between Eysenck personality type and pain sensitivity were analyzed.Results A total of 356 patients were enrolled,including 174 in A/A group,136 in A/G group and 46 in G/G group.The mutation rate of OPRM1 A118 G gene was 32.00%.There were statistically significant differences in pain sensitivity(pain threshold,pain tolerance threshold)and scores of introverted and extraverted,neurotic and dissemble personality types among three groups(P<0.05).There were significant differences in introverted and extraverted and psychotic personality types among the three groups(P<0.05).There were significant differences in pain threshold and pain tolerance threshold among different introverted,extraverted and psychotropic personality types(P<0.05).Conclusion Both OPRM1 A118 G gene polymorphism and Eysenck personality type have influence on pain sensitivity,and there is a correlation between them.