血必净联合血液净化对脓毒血症多脏器衰竭疗效观察

Therapeutic Effect of Xuebijing Combined with Blood Purification on Sepsis and Multiple Organ Failure

目的探究血必净联合血液净化运用在脓毒血症多脏器衰竭的疗效。方法选择医院2019年10月—2020年12月收治的脓毒血症多脏器衰竭患者92例,采用随机数字法的方式,分为对照组和观察组各46例。对照组采用血必净治疗,观察组采用血必净联合血液净化治疗,对比两组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)变化、临床症状消失时间、机械通气时间、入住重症加强护理病房(ICU)时间、心率、体温、白细胞、呼吸频率、多器官功能障碍综合征(MODS)发生率、脓毒症休克发生率。结果观察组IL-6、TNF-α浓度低于对照组(P<0.05);观察组临床症状消失时间、机械通气时间、入住ICU时间均低于对照组(P<0.05);观察组体温、心率、呼吸频率和白细胞均低于对照组(P<0.05);观察组MODS发生率、脓毒症休克发生率均低于对照组(P<0.05)。结论血必净联合血液净化治疗脓毒血症多脏器衰竭效果更佳。

Objective To apply Xuebijing combined with blood purification in the treatment of sepsis patients with multiple organ failure,and to explore and analyze its therapeutic effect.Methods 92 patients with sepsis and multiple organ failure in our hospital from October 2019 to December 2020 were randomly divided into control group and observation group,each 46.The control group was treated with Xuebijing and the observation group was treated with Xuebijing combined with blood purification.The changes of IL-6,TNF-αconcentration and clinical symptoms of the two groups were compared.Results The concentrations of IL-6 and TNF-α in the observation group were lower than those in the control group(P<0.05);the duration of disappearance of clinical symptoms,mechanical ventilation and ICU stay in the observation group were lower than those in the control group(P<0.05),the body temperature,heart rate,respiratory rate and white blood cells in the observation group were lower than those in the control group(P<0.05),the rates of MODS and septic shock in the observation group were lower than those in the control group(P<0.05).Conclusion Xuebijing combined with blood purification was used in the treatment of sepsis patients with multiple organ failure,which made the treatment effect better.