进食时机对口服抗肿瘤药物生物利用度影响的研究进展

Research progress on the effects of timing of taking food on the bioavailability of oral anti-tumor drugs

目的探索食物对口服抗肿瘤药物生物利用度的影响。方法检索SCI、GeenMedical、PubMed、中国知网、万方数据库,查询食物对口服抗肿瘤药物生物利用度影响的相关文献并进行汇总整理。结果食物可影响一部分口服抗肿瘤药物的生物利用度,需要空腹服用的药物有依托泊苷、替莫唑胺、索拉非尼、塞瑞替尼,需要与食物一起服用的药物有长春瑞滨、伊马替尼、维莫非尼、阿来替尼,需要避免与食物一起服用的药物有尿嘧啶替加氟、替吉奥、卡培他滨、拉帕替尼、厄洛替尼、帕唑帕尼、阿法替尼、阿帕替尼、曲美替尼、达拉非尼、依西美坦、阿比特龙。结论临床需要注意食物对口服抗肿瘤药物生物利用度的影响,指导患者合理用药,保证抗肿瘤药物的有效性和安全性。

Objective To explore the impact of food on the bioavailability of oral antit-umor drugs.Methods The relevant literatures on the effect of food on the bioavailability of oral anti-tumor drugs in SCI, GeenMedical, PubMed, CNKI and Wanfang databases were searched and sorted out.Results Food can affect the bioavailability of some oral anti-tumor drugs. Drugs that should be taken on an empty stomach include etoposide, temozolomide, sorafenib, ceritinib, and that need to be taken with food include vinorelbine, imatinib, vemurafenib, alectinib. Drugs that should be avoided taken orally with food include uracil tigafur, S-1, capecitabine, lapatinib, erlotinib, pazopanib, afatinib, apatinib, trametinib, dabrafenib, exemestane, and abiraterone.Conclusion Clinical medication should pay attention to the impact of food on the bioavailability of oral anti-tumor drugs. It is necessary to guide patients to use drugs rationally, so as to ensure the effectiveness and safety of anti-tumor drugs.