芍药汤加减治疗溃疡性结肠炎效果及对YKL-40、IL-17变化的研究

Study on Effect of Shaoyao Decoction(芍药汤) on YKL-40 and IL-17 in Patients with Ulcerative Colitis

目的研究芍药汤加减治疗溃疡性结肠炎对患者甲壳质酶蛋白40(YKL-40)、白细胞介素-17(IL-17)的变化影响。方法收集医院2018年2月—2020年1月收治的溃疡性结肠炎患者90例,分为两组。对照组给予西药治疗,研究组给予芍药汤加减辅助西药治疗。分析治疗4周后两组患者的临床效果。结果研究组总有效率为86.67%(39/45),明显高于对照组的68.89%(31/45),差异有统计学意义(P<0.05)。治疗前,两组YKL-40、核因子κB(NF-κB)及炎症因子组间比较,差异无统计学意义(P>0.05)。治疗后,组间比较发现研究组YKL-40、NF-κB、白细胞介素-1(IL-1)、IL-17、白细胞介素-23(IL-23)、C反应蛋白(CRP)水平低于对照组(P<0.05)。治疗前,两组疾病活动指数(DAI)评分组间比较,差异无统计学意义(P>0.05)。治疗后,组间比较发现研究组DAI评分低于对照组(P<0.05)。结论芍药汤加减辅助西药治疗溃疡性结肠炎可减轻炎症反应,调节YKL-40、NF-κB的表达水平,减轻疾病活动,提高疗效。

Objective To study the effect of Shaoyao Decoction(芍药汤)on the change of chitin 40(YKL-40)and interleukin-17(IL-17)in patients with ulcerative colitis.Methods From February 2018 to January 2020,90 patients with ulcerative colitis were divided into two groups.The control group was treated with western medicine,and the research group was treated with Shaoyao Decoction and adjuvant western medicine.The clinical effects of two groups after 4 weeks were analyzed.Results The total effective rate in the research group was 86.67%(39/45),significantly higher than 68.89%(31/45)in the control group(P<0.05).Before treatment,YKL-40,nuclear factor NF-κB(NF-κB)and inflammatory factors of two groups were not significant(P>0.05).After treatment,the levels of interleukin-1(IL-1),IL-17,interleukin-23(IL-23)and C-reactive protein(CRP)in the research group were lower than those in the control group(P<0.05).Before treatment,the disease activity number(DAI)scores of two groups was not significant(P>0.05).The DAI score of the research group was lower than that of the control group(P<0.05).Conclusion Shaoyao Decoction combined with western medicine in the treatment of ulcerative colitis can reduce inflammatory reaction,regulate the expressions of YKL-40 and NF-κB,reduce DAI and improve the curative effect.