右美托咪定在脓毒症治疗中的作用及机制研究进展

Research progress on the role and mechanism of dexmedetomidine in the treatment of sepsis

脓毒症是因机体对感染反应失调而导致的危及生命的器官功能障碍,是临床急危重患者常见的并发症。脓毒症期间患者脑、肺、肾、肝等都会不同程度地受到损伤,免疫功能发生紊乱。大量研究表明,右美托咪定(DEX)对脓毒症患者具有一定的保护作用,可减轻脑、肺、肾、肝等的损伤以及免疫功能紊乱。现就DEX在脓毒症治疗中的作用及机制方面的研究进展进行综述。

Sepsis s a life-threatening organ dysfunction caused by the imbalance of the body’s response to infection.It is a common complication in clinical acute and critical patients.During sepsis,patients’brain,lung,kidney and liver will be damaged to varying degrees,and their immune function will be disordered.A large number of studies have shown that dexmedetomidine(DEX)has a certain protective effect on patients with sepsis,and can reduce the injury of brain,lung,kidney and liver and immune dysfunction.This paper reviews the research progress on the role and mechanism of DEX in the treatment of sepsis.