芳香羧酸脱羧-偶联反应研究

Study on the Decarboxylation-coupling Reaction of Aromatic Carboxylic Acid

芳香族羧酸脱羧-偶联反应能够有效构建C—C或C-杂原子键,在天然活性物质、药物中间体以及特殊材料合成等方面具有重要意义,并且该方法具有很好的区域选择性、原子经济性及环境友好性等特点。近年来以芳香羧酸为基本原料的脱羧-偶联反应得到深入研究,新颖催化剂不断涌现,反应条件不断完善,为该类反应的应用提供了理论依据。从偶联反应的类型、机理、不同过渡金属催化剂等方面展开综述,为进一步研究并开发该类反应提供参考。

The decarboxylation-coupling reaction of aromatic carboxylic acid can effectively construct C—C or C-heteroatomic bonds,which is of great significance in natural active substances,drug intermediates and special material synthesis,and the method is featured by good regional selectivity,atomic economy and environmental friendliness.In recent years,the decarboxylation-coupling reaction with aromatic carboxylic acid has been deeply studied,and many novel catalysts are constantly emerging,providing a theoretical basis for the application of such reactions.In order to provide a meaningful reference for further research,coupling reaction type,mechanism and the different transition metal catalysts are summarized in this mini-review.