耐多药肺结核应用莫西沙星、卷曲霉素及化疗改善肺功能与炎性指标水平的研究

Study on Improvement of Lung Function and Inflammatory Index Levels in Multi-Drug Resistant Tuberculosis by Moxifloxacin, Capreomycin and Chemotherapy

目的:研究耐多药肺结核患者采用莫西沙星、卷曲霉素及化疗改善肺功能与炎性指标水平的效果。方法:选取2019年3月-2020年3月接受化疗的耐多药肺结核患者76例,以随机抽取方式进行对等分组,各38例。对照组给予莫西沙星治疗,试验组给予莫西沙星与卷曲霉素联合治疗。观察两组患者血清炎性因子水平[白细胞介素-1(IL-1)、白细胞介素-17(IL-17)、C-反应蛋白(CRP)]及肺功能[用力肺活量(FVC)、第1秒呼气容积占比(FEV1)及第1秒用力呼气量占用力肺活量比值(FEV1/FVC)]变化情况。结果:治疗后,试验组IL-1、IL-17、CRP水平相较于对照组明显更优,差异有统计学意义(P<0.05);试验组FVC、FEV1及FEV1/FVC水平相较于对照组明显更高,差异有统计学意义(P<0.05)。结论:耐多药肺结核患者在化疗基础上给予莫西沙星与卷曲霉素联合治疗可有效降低患者血清炎性指标水平,促进其肺功能改善,对疾病治疗具有积极作用,值得推广。

Objective: To study the effect of moxifloxacin, capreomycin and chemotherapy on improving lung function and inflammatory index levels of patients with multi-drug resistant tuberculosis. Methods: Seventy-six patients with multi-drug resistant tuberculosis who received chemotherapy from March 2019 to March 2020 were selected and randomly divided into two equal groups, with 38 cases in each group. Control group was treated with moxifloxacin and experimental group was treated with moxifloxacin and capreomycin. Serum inflammatory factor levels [interleukin-1(IL-1), interleukin-17(IL-17), C-reactive protein(CRP)] and lung function(forced vital capacity(FVC), forced expiratory volume in 1 second(FEV1) and forced expiratory volume in1 second to forced vital capacity ratio(FEV1/FVC)] changes of patients in the two groups were observed. Results: After treatment,the levels of IL-1, IL-17 and CRP in experimental group were significantly better than those in control group, with statistically significant difference(P<0.05);the levels of FVC, FEV1 and FEV1/FVC in experimental group were significantly higher than those in control group, with statistically significant difference(P<0.05). Conclusion: The combined treatment of moxifloxacin and capreomycin on the basis of chemotherapy for patients with multi-drug resistant tuberculosis can effectively reduce the level of serum inflammatory indexes, promote the improvement of their lung function, and have a positive effect on the treatment of the patient’s disease. It is worthy of promoting.