依折麦布联合阿托伐他汀片对合并急性冠状动脉综合征降脂效果分析

Analysis on Lipid-Lowering Effects of Ezetimibe Combined with Atorvastatin in Complicated Acute Coronary Syndrome

目的:分析依折麦布联合阿托伐他汀片对合并急性冠状动脉综合征降脂的疗效。方法:将2018年12月-2020年4月收治的72例急性冠状动脉综合征合并高脂血症患者作为研究对象,应用随机数表法分为两组,各36例。观察组给予依折麦布片联合阿托伐他汀片治疗;对照组采用阿托伐他汀片治疗。观察两组患者治疗效果,血脂指标(高密度脂蛋白胆固醇、总胆固醇、低密度脂蛋白胆固醇),生活质量。结果:观察组治疗后总有效率高于对照组(P<0.05)。两组治疗后高密度脂蛋白胆固醇、总胆固醇、低密度脂蛋白胆固醇水平相比,差异有统计学意义(P<0.05)。两组治疗后,观察组生活质量各项评分均高于对照组,差异有统计学意义(P<0.05)。结论:依折麦布联合阿托伐他汀片对合并急性冠状动脉综合征患者降脂效果显著,安全性高。

Objective: To study the lipid-lowering effect of Ezetimibe and Atorvastatin in complicated acute coronary syndrome.Methods: Seventy-two patients with acute coronary syndrome and hyperlipidemia who were admitted from December 2018 to April2020 were included in this study, and they were randomly divided into two groups according to the random digital table method,with 36 cases in each group. The observation group was given Ezetimibe combined with Atorvastatin;the control group was given Atorvastatin. The treatment effect, blood lipid indexes(high-density lipoprotein cholesterol, total cholesterol, low-density lipoprotein cholesterol) and quality of life of patients were compared between two groups. Results: The total effective rate of the observation group was higher than that of the control group(P<0.05);there were statistically significant differences in the levels of high-density lipoprotein cholesterol, total cholesterol, low-density lipoprotein cholesterol between the observation group and the control group(P<0.05). After treatment, the quality of life scores in the observation group were higher than those in the control group, with statistically significant differences(P<0.05). Conclusion: Ezetimibe combined with Atorvastatin show significant lipid-lowering effect and high safety in patients with complicated acute coronary syndrome.