绿茶与肝癌发生风险相关关系的Meta分析

Correlation between green tea and the risk of liver cancer:a Meta analysis

目的:系统评价绿茶与肝癌发生风险的关系。方法:计算机检索PubMed、Web of Science、the Cochrane Library、中国知网(CNKI)、万方数据库(Wanfang Data)和中国生物医学文献数据库(CBM)中绿茶与肝癌发生风险关系的相关文献,检索时限从建库至2020年12月31日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险,采用Stata 16.0软件进行Meta分析。结果:共纳入11项前瞻性研究,共计1 674 935名参与者和5 574例肝癌病人。Meta合并结果显示,绿茶最大摄入量与肝癌发生风险降低之间存在显著相关性[RR=0.85,95%CI(0.77,0.92)]。亚组分析显示,每日绿茶最大摄入量可以降低女性肝癌的发生风险[RR=0.50,95%CI(0.30,0.71)],但在男性病人中相关性无统计学意义[RR=0.83,95%CI(0.60,1.06)]。当每日摄茶量≥5杯时,绿茶与肝癌发生风险有显著相关性[RR=0.71,95%CI(0.57,0.87)]。结论:现有证据表明,绿茶的摄入对女性肝癌病人具有保护作用,但该结果仍需要更多大样本、多中心的研究继续验证。

Objectives:To evaluate the relationship between green tea and the risk of liver cancer. Methods:Literatures on the relationship between green tea and the risk of liver cancer were searched in PubMed,Web of Science,the Cochrane Library,CNKI,Wanfang Data and CBM. The retrieval time was from the establishment of the database to December 31,2020. Two researchers independently screened literatures,extracted data and evaluated the risk of bias in the included studies. Stata 16. 0 software was used for Meta analysis. Results:A total of 11 prospective studies involving 1,674,935 participants and 5,574 liver cancer patients were included. Meta-analysis showed that,there was a significant association between maximum green tea intake and reduced risk of liver cancer[RR=0. 85,95%CI(0. 77,0. 92)]. Subgroup analysis showed that the maximum daily intake of green tea was associated with a lower risk of liver cancer in women[RR=0. 50,95%CI(0. 30,0. 71)],but that was not statistically significant in men[RR=0. 83,95%CI(0. 60,1. 06)]. When tea intake≥5 cups per day,green tea was significantly associated with liver cancer risk[RR=0. 71,95%CI(0. 57,0. 87)]. Conclusion:Current evidence showed that green tea intake was protective in women with liver cancer,but more large,multicenter studies are needed to confirm these results.