缓解期溃疡性结肠炎患者功能性肠道症状调查分析

Investigation and analysis of functional intestinal symptoms in patients with remission ulcerative colitis

目的了解缓解期溃疡性结肠炎(UC)患者功能性肠道症状发生的频率,并探讨其与患者抑郁、焦虑及生活质量相关性。方法选取2016年5月至2020年3月徐州医科大学附属淮安医院就诊的临床缓解期UC患者326例,并选取其中无功能性肠道症状患者20例为对照组。采用一般资料调查表、医院焦虑和抑郁量表、大便失禁评分量表、粪失禁生活质量评分系统、便秘患者生活质量自评问卷对患者进行调查。采用Pearson相关性分析功能性肠道症状与抑郁、焦虑及生活质量的相关性。结果共收回有效问卷300例,8%患者出现过大便失禁症状,10%患者出现过便秘。有功能性肠道症状患者焦虑评分、抑郁评分显著高于对照组患者,差异均有统计学意义(P<0.05);有功能性肠道症状患者生活质量显著低于对照组患者,差异有统计学意义(P<0.05)。Pearson相关性分析结果显示,患者大便失禁及便秘评分与焦虑、抑郁评分均呈显著正相关(P<0.01);大便失禁评分与生活质量评分呈显著负相关(r=-0.863,P<0.01),便秘评分与生活质量分呈显著正相关(r=0.881,P<0.01)。结论缓解期UC患者仍会出现功能性肠道症状,并且功能性肠道症状增加了患者负性情绪,影响了患者生活质量。

Objective To investigate the frequency of functional intestinal symptoms in patients with ulcerative colitis in remission stage and its correlation with depression,anxiety and quality of life.Methods A total of 326 patients with ulcerative colitis in remission stage from May 2016 to March 2020 were selected,and 20 patients without functional intestinal symptoms were selected as the control group.General information questionnaire,hospital anxiety and depression scale,fecal incontinence score scale,fecal incontinence quality of life score system and constipation patients quality of life questionnaire were used to investigate the patients.Pearson correlation analysis was used to analyze the correlation between functional intestinal symptoms and depression,anxiety and quality of life.Results A total of 300 valid questionnaires were collected,8%of the patients had symptoms of fecal incontinence,and 10%of the patients had constipation.The scores of anxiety and depression in patients with functional intestinal symptoms were significantly higher than those in the control group(all P<0.05).The quality of life of patients with functional intestinal symptoms was significantly lower than that of the control group(P<0.05).Pearson correlation analysis showed that the scores of fecal incontinence and constipation were positively correlated with the scores of anxiety and depression(P<0.01).There was a significant negative correlation between fecal incontinence score and quality of life score(r=-0.863,P<0.01),and a significant positive correlation between constipation score and quality of life score(r=0.881,P<0.01).Conclusion Patients with remission UC still have functional intestinal symptoms,and functional intestinal symptoms increase the negative emotions of patients and affect the quality of life of patients.