非酒精性脂肪性胰腺疾病的研究进展

Research progress of nonalcoholic fatty pancreas disease

非酒精性脂肪性胰腺疾病(NAFPD)是指与肥胖症或代谢综合征相关的胰腺脂肪堆积。近年来随着人们生活水平的提高,NAFPD发病率也在不断增加,与其相关的研究也随之增加。目前其发病机制尚不明确,定量评估方法主要包括组织学检查、超声、CT、MRI等,近年来文献报道NAFPD与疾病的相关性主要集中于2型糖尿病、动脉粥样硬化、代谢综合征、胰腺癌、胰腺内分泌与外分泌功能、非酒精性脂肪肝、急慢性胰腺炎、胰瘘等。与肝脏脂肪变性相比,NAFPD相关研究数量依然较少。

Nonalcoholic fatty pancreas disease(NAFPD)refers to the accumulation of pancreatic fat related to obesity or metabolic syndrome.In recent years,with the improvement of people′s living standards,its incidence is also increasing,and the related research is also increasing.At present,its pathogenesis is unclear,and the quantitative evaluation methods mainly include histological examination,ultrasound,CT,MRI,etc.According to studies in recent years,its correlation with diseases mainly focuses on type 2 diabetes,atherosclerosis,metabolic syndrome,pancreatic cancer,pancreatic endocrine and exocrine function,nonalcoholic fatty liver,acute and chronic pancreatitis,pancreatic fistula and so on.Compared with hepatic steatosis,the number of studies related to NAFPD is still small.