胃癌组织中成纤维细胞生长因子受体样蛋白1的表达及其与术后复发转移的关系

Expression of fibroblast growth factor receptor-like protein 1 in gastric cancer and its relationship with postoperative recurrence and metastasis

目的探究胃癌组织中成纤维细胞生长因子受体样蛋白1(fibroblast growth factor receptor-like protein 1,FG-FRL-1)的表达及与胃癌根治术后复发转移的相关性。方法选取2016年3月至2018年6月江苏省无锡市惠山区人民医院收治的92例拟行根治术治疗的胃癌患者。对比胃癌组织和癌旁组织(距癌组织≥5cm)FGFRL-1 mRNA表达水平。随访3年(3例失访),统计胃癌根治术后复发转移情况,并依据是否发生复发转移分为复发转移组(36例)和未复发转移组(53例)。对比复发转移组和未复发转移组患者的临床资料。多因素Logistic回归分析影响胃癌患者术后复发转移发生的危险因素。绘制受试者操作特征曲线(receiver operating characteristic curve,ROC曲线),以曲线下面积(area under the curve,AUC)评价胃癌组织中FGFRL-1 mRNA表达水平对术后复发转移的预测价值。结果胃癌组织FGFRL-1 mRNA表达水平高于癌旁组织(P<0.05)。胃癌根治术后3年复发转移发生率为40.45%。复发转移组临床分期Ⅲ期占比、低分化占比、肿瘤直径及癌组织中FGFRL-1 mRNA表达水平均高于未复发转移组(P<0.05)。多因素Logistic回归分析结果显示,临床分期、癌组织中FGFRL-1 mRNA均为胃癌患者术后复发转移发生的危险因素(OR=2.807、3.330,P<0.05)。ROC曲线分析显示,胃癌组织中FGFRL-1 mRNA表达水平预测术后复发转移发生的最佳截断点为1.21,灵敏度、特异度及AUC分别为72.22%、75.47%、0.714。结论胃癌组织中FGFRL-1 mRNA表达水平高于癌旁组织,且其与胃癌根治术后复发转移存在一定的相关性,可作为临床评估胃癌根治术后复发转移的重要参考指标。

Objective To explore the expression of fibroblast growth factor receptor-like protein 1(FGFRL-1)in gastric cancer tissue and its relationship with recurrence and metastasis after radical resection of gastric cancer.Method Ninety-two gastric cancer patients admitted to the People’s Hospital of Huishan District,Wuxi City,Jiangsu Province,from March 2016 to June 2018,who were to be treated with radical gastrectomy,were selected.The expression levels of FGFRL-1 m RNA in gastric cancer tissues and paraneoplastic tissues(≥5 cm from the cancer tissue)were compared.The patients were divided into recurrent metastasis group and non-recurrent metastasis group according to whether recurrent metastasis occurred during 3 years of follow-up and clinical data were compared between the two groups.Logistic multivariate regression analysis was performed to analyze the risk factors affecting the occurrence of recurrent metastasis of postoperative recurrence and metastasis of gastric cancer patients.A receiver operator characteristic(ROC curve)was drawn,and the area under the curve(AUC)was used to evaluate the predictive value of FGFRL-1 mRNA expression in gastric cancer tissues for postoperative recurrence and metastasis.Result The expression level of FGFRL-1 m RNA in gastric cancer tissue was higher than that in adjacent tissues(P <0.05).The incidence of recurrence and metastasis 3 years after radical gastric cancer was 40.45%.The proportion of clinical stage Ⅲ,poor differentiation,tumor diameter,and FGFRL-1 m RNA expression in the recurrence and metastasis group were higher than those in the non-recurrence and metastasis group(P<0.05).Logistic regression analysis showed that clinical staging and FGFRL-1 m RNA were risk factors for postoperative recurrence and metastasis of gastric cancer patients(OR=2.807,3.330,P<0.05).ROC analysis showed that the best cut-off point for FGFRL-1 m RNA expression in gastric cancer tissue to predict postoperative recurrence and metastasis was 1.21,and the sensitivity,specificity and AUC were 72.22%,75.47% and 0.714,respectively.Conclusion The expression level of FGFRL-1 m RNA in gastric cancer tissue is higher than that in paraneoplastic tissues,and it correlates with recurrence and metastasis after radical gastrectomy.It can be used as an important indicator for clinical assessment of recurrence and metastasis after radical gastrectomy.