血清Cys-C、VEGF、CA153在乳腺癌诊断中的价值

Valua of serum Cys-C,VEGF and CA153 in the diagnosis of breast cancer

目的探讨血清胱抑素C(Cys-C)、内皮细胞生长因子(VEGF)、糖类抗原153(CA153)在乳腺癌诊断中的价值。方法选取2018年6月至2020年11月该院74例乳腺癌患者作为观察组,另选取同期74例体检健康者作为对照组。比较两组血清Cys-C、VEGF、CA153水平,不同TNM分期乳腺癌患者血清Cys-C、VEGF、CA153水平,比较血清Cys-C、VEGF、CA153单独检测与联合检测的检出率,分析血清Cys-C、VEGF、CA153水平和TNM分期的相关性。结果观察组血清Cys-C、VEGF、CA153水平均高于对照组(P<0.05);TNMⅠ~Ⅱ期患者血清Cys-C、VEGF、CA153水平较TNMⅢ~Ⅳ期患者低(P<0.05);3项指标联合测诊的检出率为90.54%,均高于各项单独检测(P<0.05);Pearson相关分析结果显示,血清Cys-C(r=0.598)、VEGF(r=0.623)、CA153(r=0.619)和乳腺癌TNM分期呈正相关(P<0.05)。结论乳腺癌患者血清Cys-C、VEGF、CA153水平较健康女性高,并和TNM分期有关,而3项联合检测的乳腺癌检出率较高,可为临床乳腺癌筛查提供参考依据。

Objective To investigate the value of serum cystatin C(Cys-C),endothelial cell growth factor(VEGF),carbohydrate antigen 153(CA153)in the diagnosis of breast cancer.Methods A total of 74 patients with breast cancer in the hospital from June 2018 to November 2020 were selected as the observation group,and 74 healthy subjects in the same period were selected as the control group.The levels of serum Cys-C,VEGF and CA153 were compared between the two groups,the levels of serum Cys-C,VEGF and CA153 in breast cancer patients with different TNM stages were compared,and the detection rates of serum Cys-C,VEGF and CA153 were compared between single detection and combined detection.The correlation between serum Levels of Cys-C,VEGF,CA153 and TNM stage was analyzed.Results The levels of serum Cys-C,VEGF and CA153 in observation group were higher than those in control group(P<0.05).The levels of Serum Cys-C,VEGF and CA153 in TNMⅠ-Ⅱpatients were lower than those in TNMⅢ-Ⅳpatients(P<0.05).The combined detection rate of the three indicators was 90.54%,which was higher than that of the single detection(P<0.05).Pearson correlation analysis showed that serum Cys-C(r=0.598),VEGF(r=0.623),CA153(r=0.619)were positively correlated with TNM stage of breast cancer(P<0.05).Conclusion The serum levels of Cys-C,VEGF and CA153 in breast cancer patients are higher than those in healthy women,and are significantly correlated with TNM stage.The combined detection rate of the three indicators is higher,which could provide a reference for clinical breast cancer screening.