H型高血压患者MTHFR基因C677T多态性与Hcy及血脂水平的关系

Relationship between MTHFR gene C677T polymorphism with Hcy and blood lipid level in patients with H-type hypertension

目的分析宿迁地区H型高血压患者亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与血清同型半胱氨酸(Hcy)及血脂水平的关系。方法选择2018年1月至2019年12月在徐州医科大学附属宿迁医院就诊的H型高血压患者404例,检测Hcy及血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,并留取2 mL全血检测MTHFR C677T基因型,对结果进行统计学分析。结果MTHFR基因C677T的TT型患者血清Hcy水平均明显高于CT、CC型(P<0.05),而CC型患者血清Hcy水平与CT型比较差异均无统计学意义(P>0.05)。TT型患者血清TC、TG、HDL-C、LDL-C水平与CT、CC型比较差异均无统计学意义(P>0.05)。对所有患者年龄(<65岁和≥65岁)、性别进行分层分析,不同年龄(<65岁和≥65岁)、性别TT型患者血清Hcy水平与CT、CC基因型比较差异均有统计学意义(P<0.05);不同年龄(<65岁和≥65岁)、性别不同基因型患者TC、TG、HDL-C、LDL-C水平比较,仅≥65岁TT型患者HDL-C水平与CT、CC型比较差异有统计学意义(P<0.05)。结论H型高血压患者的MTHFR基因C677T多态性与血清Hcy水平相关,同时在≥65岁老年人群中MTHFR基因C677T多态性与血清HDL-C水平有关,而与TC、TG、LDL-C水平无关。

Objective To explore the relationship between methylenetetrahydrofolate reductase(MTHFR)gene C677T polymorphism with serum homocysteine(Hcy)and blood lipid levels in the patients with H-type hypertension in Suqian area.Methods A total of 404 patients with H-type hypertension in this hospital from January 2018 to December 2019 were selected.Serum Hcy,total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)were detected.Preserved 2 mL of whole blood for detecting MTHFR genotype,and the statistical software was used to analyze the results.Results The serum Hcy level in the patients with TT genotype of MTHFR gene C677T was significantly higher than that in the patients with CT and CC genotypes(P<0.05),whereas there was no statistically significant difference in serum Hcy level between the patients with CT genotype and the patients with CC genotype(P>0.05).There was no statistically significant difference in serum TC,TG,HDL-C and LDL-C levels between the patients with TT genotype with the patients with CT and CC genotypes(P>0.05).The stratification analysis was performed on all ages(<65 years old and≥65 years old)and gender,the serum Hcy level in the patients with TT genotype was statistically significant difference compared with that in the patients with CT and CC genotypes(P<0.05).In the comparison of serum TC,TG,HDL-C and LDL-C level among different ages(<65 years old and≥65 years old)and different sexes of the patients,the HDL-C level only had statistical difference between the patients with TT genotype aged≥65 years old and the patients with CT and CC genotypes(P<0.05).Conclusion The MTHFR gene C677T polymorphism in the patients with H-type hypertension is significantly correlated with serum Hcy level,meanwhile in the population aged≥65 years old,MTHFR gene C677T polymorphism is related with serum HDL-C level and has no relation with the TC,TG and LDL-C levels.