益气健脾中药并热灌注化疗联合TACE治疗胃癌肝转移的临床应用价值

Clinical Value of Qi-benefiting Spleen-invigorating Herbs Combined with Hyperthermic Perfusion Chemotherapy and TACE in the Treatment of Liver Metastasis of Gastric Cancer

目的:分析益气健脾中药并热灌注化疗联合肝动脉插管化疗栓塞(transcatheter arterial chemoembolization,TACE)治疗胃癌肝转移的临床应用价值。方法:选择胃癌肝转移患者72例,随机分为观察组和对照组,各组36例。对照组采用常规TACE疗法,观察组采用益气健脾中药并热灌注化疗联合TACE治疗,比较两组临床总有效率,肿瘤细胞因子[缺氧诱导因子2α(hypoxia inducible factor-2α,HIF-2α)、可溶性白细胞介素2受体(soluble interleukin-2 receptor,sIL-2R)、血管内皮生长因子(vascular endothelial growth factor,VEGF)]、免疫功能指标[CD3^(+)、CD4^(+)/CD8^(+)]水平及不良反应发生情况。结果:观察组总有效率[55.56%(20/36)]明显高于对照组[27.78%(10/36)](P<0.05)。治疗后,两组HIF-2α、sIL-2R及VEGF水平均降低,且观察组治疗后HIF-2α、sIL-2R及VEGF水平与治疗前及对照组治疗后比较,差异有统计学意义(P<0.05)。两组治疗后CD3^(+)、CD4^(+)/CD8^(+)水平上升,观察组治疗后CD3^(+)、CD4^(+)/CD8^(+)水平与治疗前及对照组治疗后比较,差异有统计学意义(P<0.05)。观察组不良反应发生率[27.78%(10/36)]明显低于对照组[52.78%(19/36)](P<0.05)。结论:益气健脾中药并热灌注化疗联合TACE治疗胃癌肝转移可以降低患者肿瘤细胞因子水平,提高相应免疫功能水平,降低不良反应发生率,提高临床治疗有效率。

Objective:To analyze clinical value of Qi-benefiting spleen-invigorating herbs,hyperthermic perfusion chemotherapy and TACE in the treatment of liver metastasis of gastric cancer.Methods:All 72 patients were chosen,randomized into the observation group and the control group,36 cases in each group.the control group adopted conventional TACE therapy,and the observation group used Qi-benefiting spleen-invigorating herbs,hyperthermic perfusion chemotherapy and TACE,to compare total effective rates,tumor cytokines(HIF-2αand sIL-2R),VEGF,immune function indexes(CD3^(+),CD4^(+)/CD8^(+))and adverse reaction in both groups.Results:Total effective rate of the observation group was[55.56%(20/36)],obviously higher than[27.78%(10/36)]of the control group(P<0.05).After the treatment,the levels of HIF-2α,sIL-2R and VEGF lowered in the two groups,and the difference had statistical meaning in the levels of HIF-2α,sIL-2R and VEGF when the observation group after treating was compared with before treating,and the control group after treating(P<0.05).The levels of immune function indexes CD3^(+),CD4^(+)/CD8^(+)increased in two groups after treating,when the levels of CD3^(+),CD4^(+)/CD8^(+)of the observation group after treating were compared with before treating and the control group after treating,the difference had statistical meaning(P<0.05).The incidence of adverse reaction of the observation group was[27.78%(10/36)],notably lower than[52.78%(19/36)]of the control group(P<0.05).Conclusion:Qibenefiting spleen-invigorating herbs,hyperthermic perfusion chemotherapy and TACE could lower tumor cytokines,raise the levels of immune function,reduce the incidence of adverse reaction and lift clinical therapeutic effective rate in the treatment of liver metastasis of gastric cancer.