外周血白细胞计数水平与高血压风险相关性的meta分析

Correlation between peripheral white blood cell count and risk of hypertension:a meta-analysis

目的系统评价外周血白细胞计数水平与高血压发生风险的关系。方法计算机检索中国知网、万方数据库、维普中文科技期刊数据库,Pubmed、Embase以及Cochrane Library数据库中公开发表的有关外周血白细胞计数与高血压发病风险的流行病学观察性研究,由2位研究者按照文献的纳入及排除标准独立进行文献的筛选,提取相关数据并采用纽卡斯尔-渥太华量表对纳入的文献质量进行评价。运用Stata 12.0软件进行meta分析。结果共纳入10篇文献,其中包括11项研究(7项队列研究,1项巢式病例对照研究,1项病例对照研究,2项横断面研究),共纳入研究对象96 285例,其中包括23 861例高血压患者。使用随机效应模型对各效应量进行合并。结果显示:外周血白细胞计数最高组发生高血压的风险较白细胞计数最低组高34%(RR=1.34, 95%CI:1.21~1.48);白细胞计数每增加1×10^(9)/L,高血压的发生风险增加6%(RR=1.06, 95%CI:1.01~1.12)。结论外周血白细胞计数水平与高血压的发生风险相关,白细胞计数水平升高可增加高血压的发生风险。

Objective To systematically evaluate the relationship between peripheral white blood cell (WBC) count and the risk of hypertension. Methods China National Knowledge Infrastructure,Wanfang database,Weipu database,PubMed,Embase and the Cochrane Library were searched for epidemiological observational studies focusing on the relationship between peripheral WBC count and risk of hypertension. Two researchers independently selected the literatures based on the criteria for inclusion and exclusion,then extracted the related data and evaluated the quality of the included literatures according to the Newcastle-Ottawa Scale. A meta-analysis was performed by using Stata 12.0 software. Results A total of 10 articles were enrolled,including 11 studies( namely,7 cohort,1 nested case-control,1 case-control and 2 cross-sectional studies). A total of 96,285 participants were involved,including 23,861 hypertension patients. A random effects model was used to calculate the pooled effect value. The results showed that the risk of hypertension in the group with the highest WBC count was 34% higher than that in the group with the lowest WBC count( RR = 1.34,95%CI: 1.21-1.48). The risk of hypertension increased by 6%( RR = 1.06,95%CI: 1.01-1.12)for every 1× 10^(9)/L increase in WBC count. Conclusion The level of peripheral WBC count is associated with the risk of hypertension. The elevated WBC count may increase the risk of hypertension.