依达拉奉联合舒血宁注射液治疗脑梗死的临床疗效及其对神经功能、血脂的影响

Clinical efficacy and impact on neurological function and blood fat of edaravone combined with Shuxuening injection in the treatment of cerebral infarction

目的探讨依达拉奉联合舒血宁注射液治疗脑梗死的临床疗效及其对神经功能、血脂的影响。方法选取黑龙江省中医药科学院2018年10月—2020年10月收治的脑梗死患者80例,按照随机数字表法分为对照组与观察组,各40例。对照组予以依达拉奉注射液治疗,观察组在对照组治疗基础上联合舒血宁注射液治疗。2组均治疗2周。比较2组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、血脂指标[三酰甘油(TG)和总胆固醇(TC)]、血管生成素(Ang)-2、神经元特异性烯醇化酶(NSE),并观察2组不良反应发生情况。结果治疗前,2组NIHSS评分比较,差异无统计学意义(P>0.05);治疗后,对照组、观察组NIHSS评分分别低于同组治疗前,且观察组NIHSS评分低于对照组(P<0.05)。治疗前,2组TG、TC比较,差异无统计学意义(P>0.05);治疗后,对照组、观察组TG、TC分别低于同组治疗前,且观察组TG、TC低于对照组(P<0.05)。治疗前,2组Ang-2、NSE比较,差异无统计学意义(P>0.05);治疗后,对照组、观察组Ang-2分别高于同组治疗前,NSE分别低于同组治疗前,且观察组Ang-2高于对照组,NSE低于对照组(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论依达拉奉联合舒血宁治疗脑梗死的临床疗效确切,可有效改善神经功能,降低血脂水平,提高Ang-2水平,且安全性较高。

Objective To investigate the clinical efficacy and impact on neurological function and blood fat of edaravone combined with Shuxuening injection in the treatment of cerebral infarction.Methods A total of 80 cases of patients with cerebral infarction were selected from October 2018 to October 2020 in Heilongjiang Academy of Traditional Chinese Medicine,which were divided into control group and observation group according to the random number table method,with 40 cases in each group.The control group was treated with edaravone injection,the observation group was treated with Shuxuening injection on the basis of the control group.Both groups were treated for 2 weeks.National institutes of health stroke scale(NIHSS)score,blood fat(TG,TC),angiopoietin(Ang)-2,neuron-specific enolase(NSE)before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results Before treatment,there was no significant difference in NIHSS scores between the two groups(P>0.05);after treatment,the NIHSS scores of the control group and the observation group were lower than those before treatment,and the NIHSS scores of the observation group were lower than those of the control group(P<0.05).Before treatment,there was no significant difference in TG and TC between the two groups(P>0.05);after treatment,TG and TC in the control group and the observation group were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference in Ang-2 and NSE between the two groups(P>0.05);after treatment,Ang-2 in observation group was higher than that in control group and NSE was lower than that in control group(P<0.05).The incidence of adverse reactions in observation group was lower than that in control group(P<0.05).Conclusion Edaravone combined with Shuxuening injection have an exact clinical effect for cerebral infarction,which can effectively improve nerve function,reduce blood lipid level and increase Ang-2 level,and has high safety.