新型抗肿瘤药物所致心脏毒性及分子机制研究进展

Advances in Study on Novel Anti-Tumor Drugs-Induced Cardiotoxicity and Molecular Mechanisms

肿瘤已经成为人类最大致死原因,发病率与死亡率均呈持续上升趋势。基于目前恶性肿瘤的治疗,传统化疗药物已不能完全满足临床需求。新型抗肿瘤药物靶向特定部位,一定程度上减少了毒副作用,显著改善了肿瘤患者的死亡率和不良预后。然而此类药物所致心血管毒性尤其是心脏毒性已经成为影响患者生存期及预后的一个重要因素,由此引起了越来越多学者的关注。笔者通过归纳分析最新发表文献对新型抗肿瘤药物所致心脏毒性和分子机制的研究进行综述。

Cancer has become the world′s largest cause of human death, for which the morbidity and mortality are rising. Based on the current treatment regimens of malignant tumors, traditional chemotherapy drugs can not fully meet the clinical needs. Novel anti-tumor drugs targeting specific sites, to a certain extent, reduce toxic and side effects, and significantly improve the mortality and poor prognosis of cancer patients. However, cardiovascular toxicity caused by such drugs, especially cardiotoxicity, has become an important factor affecting the survival and prognosis of patients, thus attracting more and more scholars′ attention. This review will highlight recent research of cardiotoxicity caused by novel antitumor drugs and the possible molecular mechanisms.