酪氨酸激酶抑制剂与器官纤维化研究进展

Advance in the Research of Tyrosine Kinase Inhibitors in Organ Fibrosis

纤维化是一种组织持续损伤修复导致的慢性疾病,多种因素刺激成纤维细胞的活化,胶原蛋白和纤连蛋白生成增多,导致细胞外基质(extracellular matrix, ECM)沉积,持续发展可能会导致器官衰竭甚至死亡。激酶活性的异常状态与许多疾病密切相关,如心血管疾病,肿瘤和代谢性疾病以及纤维化。酪氨酸激酶及其相关信号通路的活化可能加速纤维化疾病的发展进程。本研究主要阐述了酪氨酸激酶与器官纤维化的关系,以及酪氨酸激酶抑制剂在器官纤维化相关疾病中应用的研究进展。

Fibrosis is a chronic disease caused by continuous tissue damage and repair. A variety of factors stimulate the activation of fibroblasts and increase the production of collagen and fibronectin, leading to the deposition of extracellular matrix(ECM). The continuous development may lead to organ failure or even death. Abnormal state of kinase activity is closely associated with many diseases, such as, cardiovascular, tumors and metabolic diseases, and fibrosis. Activation of tyrosine kinases and their associated signaling pathways may accelerate the progression of fibrotic diseases. This paper mainly describes the relationship between tyrosine kinase and organ fibrosis, and the research progress of tyrosine kinase inhibitors in organ fibrosis.