20例成人型卵巢颗粒细胞瘤的临床病理特点与分析

Clinicopathological features and analysis of 20 cases of adult ovarian granulosa cell tumor

目的分析归纳成人型卵巢颗粒细胞瘤(AGCT)的临床病理特点,为疾病诊治提供参考。方法回顾性分析20例经手术与病理证实为AGCT患者的临床病理资料,分析该病临床病理特点和治疗方案。结果20例患者中,腹胀、腹痛7例,盆腔包块8例,阴道异常出血5例,雌激素升高者11例,疾病分期多为早期(Ⅰ期19例),均行手术治疗,4例行术后化疗。术后回访无复发。结论卵巢颗粒细胞瘤临床症状不明显,对于阴道异常出血、腹部包块、腹胀腹痛、雌激素水平升高者考虑AGCT的可能。诊断需参考影像学资料及病理组织学形态及免疫表型,注意与其他卵巢肿瘤的区别。以手术治疗为主,早期诊治复发率低,该疾病有远期复发特点,需长期随访。

Objective The clinicopathological characteristics of adult granulosa cell tumor of ovary(AGCT)were analyzed and summarized to provide reference for diagnosis and treatment of the disease.Methods The clinicopathological data of 20 patients with AGCT confirmed by surgery and pathology were retrospectively analyzed to analyze the clinicopathological characteristics and treatment plan of the disease.Results Among the 20 patients,there were 7 cases of abdominal distension and abdominal pain,8 cases of pelvic mass,5 cases of abnormal vaginal bleeding and 11 cases of elevated estrogen.Most of the disease stages were early(19 cases in stageⅠ).All patients were treated with surgery and 4 cases were treated with postoperative chemotherapy.There was no recurrence after follow-up.Conclusion The clinical symptoms of ovarian granulosa cell tumor are not obvious,and AGCT may be considered for patients with abnormal vaginal bleeding,abdominal mass,abdominal distension and abdominal pain.The diagnosis should refer to hormone levels and imaging data,and pay attention to the difference from other ovarian tumors.The disease is characterized by long-term recurrence and requires long-term follow-up.