基因甲基化检测在宫颈癌筛查中的临床应用

Clinical application of gene methylation detection in cervical cancer screening

宫颈癌是常见的恶性肿瘤之一,严重威胁女性健康,高危型人乳头瘤病毒(HPV)持续感染是引起宫颈癌的主要原因。宫颈基因甲基化程度随宫颈病变程度的增加而增加,为宫颈癌早期筛查提供了新的方法。宫颈癌的早期发现、早期诊断和早期治疗是降低死亡率并提高生存率的关键。应用宫颈癌基因甲基化检测对于降低阴道镜转诊率、减少患者过诊过治、节约医疗资源、减少女性的恐慌方面具有重要的临床意义。本文综述了国内外对宫颈癌基因甲基化研究,以便进一步了解宫颈癌发生、发展的过程,指导基因甲基化检测在宫颈癌筛查中的临床应用。

Cervical cancer is one of the common malignant tumors,which seriously threatens women's health.Persistent high-risk HPV infection is the main cause of cervical cancer.The methylation status of cervical cancer genes is closely related to the degree of cervical lesions,which provides a new method for cervical cancer screening,diagnosis,follow-up and prediction.Early detection,diagnosis and treatment of cervical cancer are the keys to reduce mortality and improve survival.The use of cervical cancer gene methylation testing has important clinical signifificance in reducing the referral rate of colposcopy and patients'over-diagnosis and treatment,saving medical resources;reducing women's panic.This article summarizes the research on cervical cancer gene methylation in domestic and foreign articles,for further understanding the process of cervical cancer occurrence and development,and guiding the clinical application of gene methylation detection in cervical cancer screening.