健康儿童睁闭眼不同状态下多频段大脑磁活动研究

A study of multi-frequency neuromagnetic brain activities in children with eyes-open and eyes-closed

目的探讨健康儿童睁眼和闭眼不同状态下的多频段大脑磁活动特征。方法记录24名健康儿童睁眼和闭眼时的脑磁图数据。应用累积源成像方法,对大脑磁活动在多个频段进行分析,包括δ(1~4 Hz)、θ(4~8 Hz)、α(8~12 Hz)、β(12~30 Hz)、低γ(30~55 Hz)和高γ(65~90 Hz)频段。结果纳入研究24名,平均年龄(10.3±2.4)岁,男14名、女10名。闭眼状态组儿童的α和β频段脑磁源绝对强度较睁眼状态组显著增加,差异有统计学意义(P<0.01)。与睁眼状态组相比,闭眼状态组儿童α和β频段脑磁源相对强度显著升高,差异有统计学意义(P<0.01)。闭眼状态组的δ、低γ和高γ频段脑磁源相对强度较睁眼状态组显著降低,差异有统计学意义(P<0.05)。各频段的脑磁源位置分布在睁、闭眼状态下差异无统计学意义(P>0.05)。结论睁眼和闭眼状态下,大脑活动在较宽的频率范围内发生显著变化。闭眼可以调节多种频率范围内的大脑生理活动。在脑磁图或脑电图的研究中,应考虑睁眼闭眼的基线条件差异。

Objective To investigate the characteristics of brain activities within multi-frequency ranges in the developing brain during eyes-open and eyes-closed.Methods The magnetoencephalography(MEG)data were recorded from 24 healthy children during eyes-open and eyes-closed.The MEG sources were localized with accumulated source imaging and analyzed in multi-frequency bands,including delta(1-4 Hz),theta(4-8 Hz),alpha(8-12 Hz),beta(12-30 Hz),low-gamma(30-55 Hz)and high-gamma(65-90 Hz).Results Twenty-four subjects(14 boys and 10 girls)were enrolled,and the average age was(10.3±2.4)years.Compared with eyes-open,the absolute source power of alpha and beta activities during eyes-closed was increased in children,and the difference was statistically significant(P<0.01).Compared with eyes-open,the relative source power of alpha and beta activities was increased(P<0.01),while the relative source power of delta,low-gamma and high-gamma activities was decreased during eyes-closed in children,and the differences were statistically significant(P<0.05).There was no significant difference in the source location distribution of each frequency band between eyes-open and eyes-closed in children(P>0.05).Conclusions The brain activity varies significantly over a wide frequency range between eyes-open and eyes-closed in children.Eye closure can regulate brain physiological activity in a wide range of frequencies.The differences in baseline conditions between eyes-closed and eyes-open should be considered in MEG or EEG studies.