一种经济有效的制备2,4,5-三氟苯乙酸的新方法

A Cost-effective New Method for Preparing 2,4,5-Trifluorophenylacetic Acid

2,4,5-三氟苯乙酸是合成治疗Ⅱ型糖尿病药物的关键中间体,同时也是合成新型含氟除草剂的重要中间体。本文以2,3,5,6-四氟对苯二甲酸二乙酯为原料,通过亲核取代、水解和脱羧三步反应得到2,4,5-三氟苯乙酸,总产率达到92%以上。该合成方法工艺简单,产率高,适合工业化生产。

2,4,5-trifluorophenylacetic acid is a key intermediate in the synthesis of drugs for the treatment of type II diabetes mellitus,and is also an important intermediate in the synthesis of novel herbicides containing fluorine.In this paper,2,4,5-trifluorophenylacetic acid was obtained from diethyl 2,3,5,6-tetrafluoroterephthalatic acid by a three-step reaction of nucleophilic substitution,hydrolysis and decarboxylation.The total yield was more than 92%.The synthesis method is simple,high yield and suitable for industrial production.