基于Web of Science的国外免疫检查点抑制剂在肺癌治疗中应用的研究现状及热点分析

Web of science-based immune checkpoint inhibitors research status and hot spot analysis of its application in the treatment of lung cancer

目的:对Web of Science自建库至今关于免疫检查点抑制剂(immune checkpoint inhibitors, ICIs)应用于肺癌治疗的相关文献进行计量学分析,并对该领域的热点和研究态势进行探讨。方法:检索Web of Science文献合集,用Excel、VOSviewer对数据进行分析。结果:经检索共得到4 698篇文献,筛选后得到有效文献1 973篇,分析结果显示ICIs应用于肺癌治疗的外文文献数量呈逐年上升趋势。收录期刊种类较多,高达334种。ICIs治疗肺癌领域的外文文献主要涉及了4个主题。结论:近年来,肺癌免疫治疗方面的研究备受关注,国外相关研究主要集中在ICIs治疗肺癌的预后标志物、ICIs联合治疗肺癌的效果、ICIs治疗肺癌的相关毒性反应以及ICIs应用于老年肺癌人群的疗效与安全性问题等方面,今后应加强各国之间的合作,使得ICIs相关毒性反应、ICIs治疗肺癌的预后因素以及联合治疗等相关研究内容成为我国乃至世界各国该领域未来研究共同努力的方向。

Objective:To conduct a quantitative analysis on the relevant literatures about the application of immune checkpoint inhibitors(ICIs)in the treatment of lung cancer from the self-built database of Web of Science, and to discuss the hot spots and research trends in this field.Methods:Retrieved the literature collection of Web of Science, and analyzed the data with Excel and VosViewer.Results:A total of 4 698 literatures were retrieved, and 1 973 effective literatures were obtained after screening.The analysis results showed that the number of foreign literatures of ICIs application in the treatment of lung cancer was increasing year by year.There were many kinds of periodicals included, up to 334.The foreign literature in the field of ICIs treatment of lung cancer mainly covers four topics.Conclusion:In recent years, much attention has been paid to research on lung cancer immunotherapy, foreign researches mainly concentrated in the prognostic biomarkers in patients with lung cancer treated with ICIs, the efficacy of combination therapy, the immune-related adverse events and the safety and efficacy in the elderly patients treated with ICIs.In the future, we should strengthen the cooperation between countries and make the toxicity of ICIs, the prognostic factors of ICIs in the treatment of lung cancer, combined chemotherapy and other related research contents become the direction of future research efforts in this field in China and even all around the world.