慢性阻塞性肺疾病患者血清胆红素水平与踝肱指数的相关性分析

Correlation between Serum Bilirubin Level and Ankle-brachial Index in Patient with Chronic Obstructive Pulmonary Disease

目的探讨慢性阻塞性肺疾病(COPD)患者血清胆红素水平与踝肱指数(ABI)的相关性。方法选取稳定期COPD患者162例,根据ABI值分为外周动脉疾病[PAD(ABI≤0.9)]组75例和非PAD组(0.9<ABI≤1.3)87例,比较两组年龄、性别、吸烟指数、血压、体质量指数(BMI)、血清C反应蛋白(CRP)、总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、肺功能参数的差异。结果PDA组年龄、SBP、CRP高于非PDA组,PDA组TBIL、DBIL、IBIL、ABI低于非PDA组(P<0.05)。相关分析显示,ABI与年龄、吸烟指数、SBP、DBP、CRP呈负相关,与TBIL、DBIL、IBIL呈正相关(P<0.05)。多元逐步回归分析显示年龄、SBP、CRP、TBIL是ABI的影响因素。结论COPD患者血清胆红素水平与ABI值有关,是动脉粥样硬化的影响因素。

Objective To explore the correlation between serum bilirubin level and ankle-brachial index in patient with chronic obstructive pulmonary disease(COPD).Methods 162 individuals with COPD were divided into two groups according to ABI,with 75 in peripheral arterial disease(PAD)group(ABI≤0.9)and 87 in non-PAD group(0.9<ABI≤1.3).Clinical data including age,gender,smoking index,blood pressure(SBP and DBP),body mass index(BMI),serum C reactive protein(CRP),total bilirubin(TBIL),direct bilirubin(DBIL),indirect bilirubin(IBIL),triglycerides(TG),cholesterol(TC),High density lipoprotein cholesterol(HDL-C),Low density lipoprotein cholesterol(LDL-C),lung function parameters and ABI were recorded and compared between the two groups.Results There were statistically significant difference in age,SBP,CRP,TBIL,DBIL,IBIL and ABI level between the two groups(P<0.05).There were no statistically significant difference in gender,smoking index,FEV1%,BMI,DBP,FEV1%,TG,TC,HDL-C,LDL-C(P>0.05).Correlation analysis indicated that ABI was negatively correlated with age,smoking index,SBP,DBP,CRP level,and ABI was positively correlated with TBIL,DBIL,IBIL level(P<0.05).Multiple stepwise regression analysis showed that ABI was significantly affected by age,CRP,SBP and TBIL level.Conclusion Serum bilirubin level and ABI are closely related in COPD patients.The detection of serum bilirubin may predict the early assessment of atherosclerosis.