肿瘤相关巨噬细胞的作用综述

Research advances in role of tumor-associated macrophages

巨噬细胞广泛参与固有免疫及适应性免疫,其表型和功能具有很大可塑性。肿瘤微环境能够诱导巨噬细胞分化,在不同微环境下巨噬细胞可分化为经典活化型(M1表型)和替代活化型(M2表型),而大量活化的巨噬细胞浸润肿瘤间质,被称为肿瘤相关巨噬细胞(tumor-associated macrophage,TAM),多具M2表型,能通过分泌多种活性物质促进肿瘤生长、侵袭和转移。肿瘤组织中巨噬细胞的表型区分及其对肿瘤发生、发展过程中作用机制的阐明,为围绕巨噬细胞展开的肿瘤靶向治疗奠定理论基础。

Macrophage is a diverse phenotype that has important functions in inherent and adaptive immunity.The macrophages can be induced into classical activation type(M1 phenotype)and alternative activation type(M2 phenotype)under different tumor microenvironment.This large number of activated macrophages infiltrate the tumor stroma and are referred to as tumor-associated macrophages.TAMs present M2 phenotype mostly and can secrete active substance to promote tumor growth,invasion and metastasis.The clarification of the role of macrophage phenotypes in tumor tissues and their developmental processes make it possible to target cancer treatment centered on macrophages.