佛山地区小学生幽门螺杆菌感染流行病学调查

The epidemiological investigation on the infection status of Helicobacter pylori in pupils in Foshan area

目的分析佛山区小学生幽门螺旋杆菌(helicobacter pylori,H.pylori)感染情况及其影响因素。方法选择佛山区小学生(6~12岁)作为研究对象,共纳入1288例研究对象。采用问卷调查小学生的家庭情况以及生活习惯等信息,采用^(13)C-尿素呼气试验检测H.pylori感染情况。根据收集的资料,比较H.pylori感染儿童与未感染儿童基本信息、社会经济因素、生活习惯等各项指标的差异,采用多因素Logistic回归分析影响H.pylori感染的独立相关因素。结果小学生H.pylori感染率为31.99%。H.pylori感染组儿童平均年龄较未感染组大(P<0.05);H.pylori感染组儿童家庭月收入较低、母亲文化程度较低、家庭常住人口较多、存在直系亲属消化道疾病史较多、饭前便后洗手者较少、专用餐具者较少、啃食手指/玩具者较多、食用蔬菜、蛋类食品较少而食用油炸/膨化食品较多。家庭月收入较低、饭前便后洗手、专用餐具、啃食手指/玩具、直系亲属消化道疾病史是影响H.pylori感染的独立相关因素。结论家庭月收入较低、啃食手指/玩具、直系亲属消化道疾病史是H.pylori感染的独立危险因素;饭前便后洗手、专用餐具是H.pylori感染的独立保护因素。

Objective To investigate the infection status of Helicobacter pylori(H.pylori)in pupils in Foshan area,and to explore its influencing factors.Methods A total of 122 primary school students(6~12 years of age)in Foshan area were enrolled in the study.Questionnaires were used to investigate the family status and living habits of the students,and 13C-urea breath test was used to detect infection status of H.pylori.The basic information,socioeconomic factors,living habits and other related in dexes were observed and compared between the children with H.pylori infection and the children without H.pylori infection.In addition multivariate Logistic regression was used to analyze the independent related factors affecting H.pylori infection.Results The infection rate of H.pylori in infection group was 31.99%,and the average age in infection group was significantly older than that in non-infection group(P<0.05).The children in infection group showed lower monthly family income,lower levels of maternal education,larger family resident population,larger number of family members with a history of digestive tract diseases,and a fewer porportion who washed hands before and after meals,a fewer porportion of special tableware,gnawing fingers/toys more frequently,taking fewer vegetables,eggs,and more fried/puffed foods.Moreover the lower family monthly income,washing hands before and after meals,special tableware,gnawing fingers/toys,and history of digestive tract diseases of immediate family members were independent factors affecting H.pylori infection.Conclusion The lower family monthly income,gnawing fingers/toys,and history of digestive tract diseases of immediate family members are independent risk factors for H.pylori infection,however,washing hands before and after meals and special tableware are independent protective factors for H.pylori infection.