药物治疗阿片类药物所致便秘的研究进展

Progress on Drug Therapy for Opioid-induced Constipation

阿片类药物所致便秘(OIC)是阿片类药物常见不良反应之一,会影响患者生活质量及后续治疗依从性。随着全球癌症患者数量增多及慢性非癌性疼痛患者阿片类药物使用率增加,OIC患者数量将随之增多。因此,如何实现有效镇痛并平衡镇痛与OIC的发生是临床亟须解决的问题之一。目前,OIC的治疗药物主要包括泻药、外周作用的μ-阿片受体拮抗剂、促分泌剂、中药等。本文主要分析了药物治疗OIC的研究进展,以期为临床有效防治OIC提供参考依据。

Opioid-induced constipation(OIC)is one of the common adverse reactions of opioids,which may affect the quality of life and follow-up treatment compliance of patients.With the rise of number of cancer patients worldwide and the increase in the use of opioids in chronic non-cancerous pain,the number of OIC patients will increase accordingly.Therefore,how to achieve effective analgesia and balance the occurrence of analgesia and OIC is one of the clinical problems that need to be resolved urgently.At present,the main therapeutic drugs for OIC mainly include oral laxatives and peripheralμ-opioid receptor antagonists,secretagogues,traditional Chinese medicines,etc.This paper mainly analyzed the drug therapy of OIC,in order to provide a reference for the effective clinical prevention and treatment of OIC.