线粒体功能障碍与脑卒中后抑郁的关系研究进展

Research Progress on the Relationship between Mitochondrial Dysfunction and Post-stroke Depression

脑卒中后抑郁(PSD)是发生于脑血管疾病后常见的一种情绪、情感障碍,核心症状主要表现为心境低落、兴趣消退、行为抑制等。大量证据表明线粒体功能障碍是抑郁症发生、发展的重要病理生理因素之一,遂提出线粒体功能障碍有可能是PSD的发病机制之一这一假说。本文将从线粒体能量代谢障碍、氧化应激、线粒体DNA缺失、损伤或突变、细胞凋亡等方面综述线粒体功能障碍与PSD的关系,为明确线粒体功能障碍在PSD发病过程中的具体作用,为今后开发靶向抗抑郁药物提供新的理论依据。

Post-stroke depression(PSD)is one of the most common emotional disorders that occurs after cerebrovascular diseases,with core symptoms mainly including low mood,loss of interest,and behavioral inhibition.A large amount of evidence indicates that mitochondrial dysfunction is one of the important pathophysiological factors in the occurrence and development of depression,so we put forward the hypothesis that mitochondrial dysfunction may be one of the pathogeneses of PSD.The article reviewed the relationship between mitochondrial dysfunction and PSD from the aspects of mitochondrial energy metabolism disorder,oxidative stress,deletions,damage or mutation of mitochondrial DNA,and apoptosis,so as to clarify the specific role of mitochondrial dysfunction in the pathogenesis of PSD and provide a new theoretical basis for the development of targeted antidepressants in the future.