神经-骨偶联机制促异位骨化进展的研究进展

Research progress of nerve-bone coupling mechanism in developing heterotopic ossification

异位骨化(HO)是一种软组织中出现异常骨组织的疾病,目前其临床治疗方式较单一且效果不佳,主要是由于其发病机制尚不明确,因此有必要深入了解HO的病理机制,从而为其临床治疗提供理论依据。近年来,大量研究显示,神经-骨偶联机制在HO的发生、发展中发挥着至关重要的作用,神经可以通过提供细胞来源、与免疫系统交联及调控棕色脂肪组织产生等方式调控骨组织中HO的形成及矿化,而骨组织也可以在此过程中对神经活动进行调控,二者之间的相互作用对HO的发生、发展有着重要的作用。本文将围绕神经-骨偶联机制促进HO发生的研究进展展开综述。

Heterotopic ossification(HO)is a disease with abnormal bone tissue in soft tissue.At present,its clinical treatment method is relatively single and ineffective,which mainly results from its pathogenesis keeps unclear.Therefore,it is necessary to explore the in-depth pathological mechanism of HO to provide the theoretical basis for its clinical treatment.In recent years,many studies have revealed that the nerve-bone coupling mechanism plays an important role in the occurrence and development of HO.Nerves can regulate the formation and mineralization of HO in bone tissue by providing cell sources,cross-linking with the immune system,and regulating the production of brown adipose tissue,while bone tissue can in turn regulate the activities of nerves in the process.The interaction between nerves and bones plays an important role in the occurrence and development of HO.This article reviewed the research progress concerning the nerve-bone coupling mechanism in the development of HO.