微RNA调控MDSCs在疾病发展中作用的研究进展

Research progress on the role of microRNA regulating MDSCs in disease development

髓源性抑制细胞(MDSCs)是一种来源于骨髓的未成熟的髓系抑制性群体细胞,对肿瘤、炎症、感染和自身免疫性疾病的免疫反应有抑制作用。MDSCs在疾病中的分子机制、潜在的扩展和功能被认为是调控免疫反应的重要手段。微RNA(miRNA)作为一种短链非编码RNA,参与调控MDSCs细胞的增殖、分化和成熟。本文就miRNA通过不同的信号途径调控MDSCs在肿瘤、炎症、感染和自身免疫性疾病中的分化、扩展和抑制功能的研究作一综述,以期为上述疾病的免疫治疗提供一种新的可能。

Myeloid-derived suppressor cells(MDSCs),a group of immature myeloid suppressor cells derived from bone marrow,have inhibitory effects on the immune response of tumors,inflammations,infections and autoimmune diseases.The molecular mechanism,potential expansion and function of MDSCs in diseases are considered to be important means to regulate the immune response.As a short non-coding RNA,microRNA(miRNA)is involved in regulating the proliferation,differentiation and maturation of MDSCs.This article reviewed the researches on miRNAs through different signal pathways that regulate the differentiation,expansion and suppression of MDSCs in tumors,inflammations,infections and autoimmune diseases,to provide a new possibility for the immunotherapy of the above diseases.