摘要
目的分析二甲双胍联合来曲唑治疗多囊卵巢综合征不孕症的临床疗效及其对患者糖脂代谢、性激素、血清脂联素(APN)、单核细胞趋化蛋白-1(MCP-1)、胰岛素样生长因子-1(IGF-1)水平的影响。方法选取北京华博医院2019年2月至2021年2月收治的84例多囊卵巢综合征不孕症患者作为研究对象,根据随机数字表法分为两组,每组42例。对照组患者使用来曲唑治疗,观察组患者使用二甲双胍联合来曲唑治疗,均治疗3个月。对比两组患者治疗3个月后临床疗效,治疗前与治疗3个月后糖脂代谢指标、性激素指标及血清APN、MCP-1、IGF-1水平的变化。结果观察组患者治疗3个月后,其临床总有效率为95.24%,高于对照组的80.95%;与治疗前比,治疗3个月后两组患者空腹血糖(FBG)、三酰甘油(TG)、糖化血红蛋白(HbA_(1c))、总胆固醇(TC)、血清黄体生成激素(LH)、雌二醇(E_(2))、卵泡刺激素(FSH)及血清MCP-1、IGF-1水平均降低,且观察组低于对照组,而血清APN水平均升高,且观察组高于对照组(均P<0.05)。结论二甲双胍联合来曲唑治疗多囊卵巢综合征不孕症的临床疗效显著,同时可改善患者糖脂代谢、性激素水平,调节相关细胞因子。
Objective To analyze the clinical efficacy of Metformin combined with Letrozole in the treatment of infertility with polycystic ovary syndrome and its effects on glucose and lipid metabolism,sex hormones,serum adiponectin(APN),monocyte chemotactic protein-1(MCP-1)and insulin-like growth factor-1(IGF-1).Methods A total of 84 infertility patients with polycystic ovary syndrome admitted to Beijing Huabo Hospital from February 2019 to February 2021 were selected as the research objects,they were divided into two groups according to random number table method,42 cases in each group.Patients in the control group were treated with Letrozole,and the patients in the observation group were treated with Metformin combined with Letrozole,all patients were treated for 3 months.The clinical efficacy 3 months after treatment,the changes of glucose and lipid metabolism indexes,sex hormone and serum APN,MCP-1 and IGF-1 levels before and 3 months after treatmen of patients were compared between two groups.Results The total clinical effective rate of patients in the observation group 3 months after treatment was 95.24%,which was higher than that 80.95%of patients in the control group;compared with before treatment,fasting blood glucose(FBG),triglyceride(TG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),serum luteinizing hormone(LH),estradiol(E2),follicle stimulating hormone(FSH)and serum MCP-1 and IGF-1 levels 3 months after treatment of patients in the two groups decreased,the observation group was lower than the control group;while the serum APN levels of patients in the two groups increased,the observation group was higher than the control group(all P<0.05).Conclusion Metformin combined with Letrozole has significant clinical efficacy in the treatment of infertility patients with polycystic ovary syndrome,which can improve the glucose and lipid metabolism,sex hormone levels and regulate the correlating cytokines.
作者
崔娟
CUI Juan(Department of Reproduction,Beijing Huabo Hospital,Beijing 100079,China)
