应用myPKFiT解析药代动力学指导血友病A患者个体化用药的进展

Application of myPKFiT in analyzing the pharmacokinetics to guide the progress of personalized medicine for patients with hemophilia A

myPKFiT是药代动力学(pharmacokinetic,PK)指导下的A型血友病管理工具,能够快速准确地输出患者PK参数和给药方案供临床参考。目前血友病A的标准治疗手段为预防治疗,然而由于个体间差异的影响,仅以体重为参考来计算凝血因子Ⅷ(FⅧ)的用量,并不能满足血友病A患者的个体化治疗需求。PK参数可以协助临床医生更好地制订个体化治疗方案,从而改善血友病患者的治疗效果和生活质量。本文将对应用myPKFiT解析PK指导血友病A患者个体化用药的进展进行概述。

myPKFiT is a hemophilia A management tool under the guidance of pharmacokinetic(PK),which can quickly and accurately output patient PK parameters and dosing schedules for clinical reference.The current standard treatment for hemophilia A is preventive treatment.However,due to the influence of differences between individuals,calculating the dosage of coagulation factorⅧ(FⅧ)based on body weight alone cannot meet the individualized treatment needs of patients with hemophilia A.PK parameters can help clinicians better formulate individualized treatment plans,thereby improving the treatment effect and quality of life of patients with hemophilia.This article will give an overview of the progress of using myPKFiT to analyze PK to guide personalized medicine for patients with hemophilia A.