移植胰腺病理学诊断标准及其进展

Diagnostic criteria and research progress on pancreas allograft pathology

胰腺移植和胰肾联合移植是治疗1型糖尿病和部分2型糖尿病及其并发症导致的肾衰竭的最佳治疗方法。胰腺移植的类型主要包括同期胰肾联合移植(SPK)、肾移植后胰腺移植(PAK)和单纯胰腺移植(PTA)。在所有的胰腺移植类型中,对移植胰腺的活组织检查(活检)仍然是明确诊断其排斥反应并与其他并发症进行鉴别的最佳方法。本文对移植胰腺活检的方法及其相关的研究进展、移植胰腺活检排斥反应诊断标准及其进展、移植胰腺主要的并发症及其病理学表现进行阐述,旨在为指导临床对上述并发症予以准确诊断,良好地保障移植胰腺和受者的长期存活提供参考。

Pancreas transplantation and pancreas-kidney transplantation are the optimal treatment for renal failure caused by type 1 diabetes mellitus,partial type 2 diabetes mellitus and their complications.Pancreas transplantation mainly includes simultaneous pancreas-kidney transplantation(SPK),pancreas transplantation after kidney transplantation(PAK)and pancreas transplantation alone(PTA).Among all types of pancreas transplantation,biopsy of pancreas allograft remains the best method for definitively diagnosing rejection and differentiate it from other complications.In this article,biopsy methods of pancreas allograft and related research progress,diagnostic criteria and research progress on rejection of pancreas allograft biopsy,and main complications and pathological manifestations of pancreas allograft were illustrated,aiming to provide reference for guiding the clinical diagnosis of the above mentioned complications and ensuring the long-term survival of pancreas allografts and recipients.