微囊化胰岛移植优化策略研究进展

Research progress on optimization strategies for microencapsulated islet transplantation

胰岛移植是治疗糖尿病的有效方案之一,但目前仍存在供者短缺以及长期应用免疫抑制剂所致的不良反应等问题,导致移植后胰岛存活受限。微囊化胰岛移植技术可在一定程度上克服这些困难,但微囊内免疫隔离微环境破坏、氧气和营养物质供应不足等多种因素限制了微囊化胰岛移植的临床应用。近年来,关于提高微囊化胰岛移植效果的研究逐渐增多,干细胞在微囊化胰岛移植中的应用也逐步成为研究热点。因此,本文围绕微囊化胰岛移植的优化策略及干细胞在微囊化胰岛移植中的应用进行综述,探讨微囊化胰岛移植潜在的改进方法,旨在为微囊化技术在胰岛移植中的进一步临床应用研究提供参考。

Islet transplantation is one of the effective therapies for diabetes mellitus.Nevertheless,multiple issues still exist,such as shortage of donors and adverse reactions caused by long-term use of immunosuppressants,which limit the islet survival post-transplantation.Microencapsulated islet transplantation may overcome these difficulties to certain extent,whereas many factors,such as the destruction of immune isolation microenvironment within the microcapsules and insufficient supply of oxygen and nutrients,constrain the application of microencapsulated islet transplantation in clinical practice.In recent years,how to enhance the effect of microencapsulated islet transplantation has been gradually studied.The application of stem cells in microencapsulated islet transplantation has steadily become a research hot spot.Therefore,the optimizing strategies for microencapsulated islet transplantation and the application of stem cells in microencapsulated islet transplantation were reviewed,and the potential improvement techniques of microencapsulated islet transplantation were investigated in this article,aiming to provide reference for further clinical application of microencapsulated islet transplantation.