脂肪组织细胞外基质水凝胶的制备、检测和应用

Preparation,characterization and application of adipose tissue extracellular matrix derived hydrogel

细胞外基质水凝胶生物活性支架材料,以其优良的生物活性、生物相容性、生物诱导活性、生物可降解性和可微创注射等优势,被广泛应用于细胞三维培养、类器官构建、组织缺损修复、生物三维打印和组织工程等方面。脂肪组织具有来源充足、易于获取、细胞外基质成分含量丰富等优点,成为近年来组织修复和再生医学领域的研究热点,该文就其制备、检测及应用等方面进行综述,以期为相关研究人员提供参考。

Extracellular matrix hydrogel has been widely used in three-dimensional cell culture,organoid construction,tissue defect repair,biological three-dimensional printing and tissue engineering due to its excellent bioactivity,biocompatibility,bioinducibility,biodegradability and minimally invasive injection.Adipose tissue has the advantages of sufficient sources,easy access,and rich content of extracellular matrix components.It has become a research hotspot in the field of tissue repair and regenerative medicine in recent years.This article reviews its preparation,detection and application,in order to provide a reference for relevant researchers.