摘要
目的探讨广西地区老年人群HbA_(1)c参考范围及筛查DM的最佳截断值。方法选取2019~2020年于我院体检的≥60岁老年人群,行75 g OGTT并检测HbA_(1)c,分为IGR组157例、T2DM组304例及健康对照组(NGT)306名。以95%参考范围制定HbA_(1)c医学参考区间,采用受试者工作特征曲线(ROC)确定HbA_(1)c筛查DM的最佳截断值。结果NGT组HbA_(1)c为(5.60±0.41)%,HbA_(1)c参考范围4.82%~6.38%。以OGTT诊断的DM患者HbA_(1)c的ROC曲线最佳截断值为6.55%,曲线下面积为0.852(95%CI 0.821~0.883),灵敏度67.1%,特异度93.1%。结论广西地区老年人群HbA_(1)c参考范围4.82%~6.38%;HbA_(1)c≥6.55%是诊断广西地区老年人群DM的最佳截断值。
Objective To explore the reference range of glycosylated hemoglobin(HbA_(1)c)and the best cut-off value for diagnosing diabetes in the elderly in Guangxi.Methods Randomly select the elderly≥60 years old who will undergo a physical examination in our hospital from 2019 to 2020,perform 75 g OGTT and detect HbA_(1)c.Taking OGTT as the gold diagnosis standard of diabetes,306 healthy elderly with normal glucose tolerance(NGT group),157 prediabetes(IGR group)and 304 diabetes(T2DM group)were enrolled.The medical reference interval of HbA_(1)c was established based on the 95%reference range.ROC curve analysis was used to determine the best cut-off value of HbA_(1)c in the diagnosis of diabetes.ResultsThe average HbA_(1)c in NGT group was(5.60±0.41)%,with reference range 4.82%~6.38%.Taking OGTT as the gold standard,the best cut-off value of HbA_(1)c for DM diagnosis is 6.55%and the area under the ROC curve is 0.852(95%CI 0.821~0.883),with sensitivity 67.1%and specificity93.1%.Conclusion The reference range of HbA_(1)c for the elderly in Guangxi is 4.82%~6.38%.HbA_(1)c≥6.55%is the best cut-off value for diagnosing diabetes in the elderly in Guangxi.
作者
郭凌霄
韦柳婷
贾绍府
张帮献
GUO Lingxiao;WEI Liuting;JIA Shaofu(Department of Laboratory Medicine,National Hospital of Guangxi Zhuang Autonomous Region,Nanning 530001,China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2022年第1期57-60,共4页
Chinese Journal of Diabetes
基金
崇左市科学技术局自筹项目(崇科攻2019005)。
关键词
糖化血红蛋白
口服葡萄糖耐量试验
参考范围
糖尿病
截断值
Glycosylated hemoglobin
Oral glucose tolerance test
Reference range
Diabetes mellitus
Cut-off value