基于网络药理学探究“菟丝子-淫羊藿”治疗白癜风的作用机制

Exploration of mechanism of“Semen Cuscutae-Herba Epimedii”in the treatment of vitiligo based on network pharmacology

目的基于网络药理学探究“菟丝子-淫羊藿”治疗白癜风的作用机制。方法通过中药系统药理学数据库与分析平台、中医药综合数据库等筛选“菟丝子-淫羊藿”的活性成分及其靶标。通过GeneCards、在线人类孟德尔遗传数据库等数据库获取白癜风的主要靶标,对交集靶标使用STRING、Cytoscape进行蛋白质-蛋白质相互作用分析,并利用David数据库对所获靶点进行分析。结果“菟丝子-淫羊藿”共有31种活性成分和222个潜在靶标,白癜风共457个靶标,提取共同靶标47个。KEGG富集筛选出23条通路,GO分析获得356个条目。结论“菟丝子-淫羊藿”可以通过多靶标、多通路治疗白癜风,为其临床开发利用提供理论基础。

Objective To explore the mechanism of“Semen Cuscutae-Herba Epimedii”in the treatment of vitiligo based on network pharmacology.Methods The active components and their targets of“Semen Cuscutae-Herba Epimedii”were screened by traditional Chinese medicine systems pharmacology database and analysis platform,traditional Chinese medicine integrated database,and other databases.The main targets of vitiligo were identified by databases such as GeneCards and online Mendelian inheritance in man,etc.STRING and Cytoscape were used for protein-protein interaction analysis,and David database was used to analyze the obtained targets.Results There were 31 active components and 222 potential targets in“Semen Cuscutae-Herba Epimedii”,and 457 targets in vitiligo,and a total of 47 common targets were extracted.A total of 23 pathways were screened by KEGG enrichment,and 356 entries were obtained by GO analysis.Conclusion“Semen Cuscutae-Herba Epimedii”can treat vitiligo through multi-target and multi-pathway,and provide theoretical basis for its clinical development and utilization.